Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Medical Biotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Biomed Pharmacother. 2021 Aug;140:111753. doi: 10.1016/j.biopha.2021.111753. Epub 2021 May 25.
Non-coding RNAs (ncRNAs) have critical role in the pathophysiology as well as recovery after ischemic stroke. ncRNAs, particularly microRNAs, and the long non-coding RNAs (lncRNAs) are critical for angiogenesis and neuroprotection, and they have been suggested to be therapeutic, diagnostic and prognostic tools in cerebrovascular diseases, including stroke. Moreover, exosomes have been considered as nanocarriers capable of transferring various cargos, such as lncRNAs and miRNAs to recipient cells, with prominent inter-cellular roles in the mediation of neuro-restorative events following strokes and neural injuries. In this review, we summarize the pathogenic role of ncRNAs and exosomal ncRNAs in the stroke.
非编码 RNA（ncRNAs）在缺血性中风的病理生理学以及康复中起着关键作用。ncRNAs，特别是 microRNAs 和长非编码 RNA（lncRNAs），对于血管生成和神经保护至关重要，并且它们被认为是脑血管疾病（包括中风）的治疗、诊断和预后工具。此外，外泌体被认为是能够将各种 cargo（如 lncRNAs 和 miRNAs）转移到受体细胞的纳米载体，在外源性刺激诱导的神经修复中发挥重要的细胞间作用。在这篇综述中，我们总结了 ncRNAs 和外泌体 ncRNAs 在中风中的致病作用。
