Serwadda D, Mugerwa R D, Sewankambo N K, Lwegaba A, Carswell J W, Kirya G B, Bayley A C, Downing R G, Tedder R S, Clayden S A, Weiss R A, Dalgleish A G
Lancet. 1985 Oct 19;2(8460):849-52. doi: 10.1016/S0140-6736(85)90122-9.
A new disease has recently been recognised in rural Uganda. Because the major symptoms are weight loss and diarrhoea, it is known locally as slim disease. It is strongly associated with HTLV-III infection (63 out of 71 patients) and affects females nearly as frequently as males. The clinical features are similar to those of enteropathic acquired immunodeficiency syndrome as seen in neighbouring Zaire. However, the syndrome is rarely associated with Kaposi's sarcoma (KS), although KS is endemic in this area of Uganda. Slim disease occurs predominantly in the heterosexually promiscuous population and there is no clear evidence to implicate other possible means of transmission, such as by insect vectors or re-used injection needles. The site and timing of the first reported cases suggest that the disease arose in Tanzania.
最近在乌干达农村地区发现了一种新疾病。由于主要症状是体重减轻和腹泻，当地称之为消瘦病。它与人类嗜T淋巴细胞病毒III型（HTLV-III）感染密切相关（71例患者中有63例），男性和女性受影响的频率相近。其临床特征与邻国扎伊尔所见的肠病性获得性免疫缺陷综合征相似。然而，该综合征很少与卡波西肉瘤（KS）相关，尽管KS在乌干达的这一地区为地方病。消瘦病主要发生在性乱交人群中，没有明确证据表明存在其他可能的传播途径，如通过昆虫媒介或重复使用的注射针头传播。首例报告病例的地点和时间表明该病起源于坦桑尼亚。
