Hernández-Lepe Marco Antonio, López-Díaz José Alberto, Rosa Laura Alejandra de la, Hernández-Torres Rosa Patricia, Wall-Medrano Abraham, Juarez-Oropeza Marco Antonio, Pedraza-Chaverri José, Urquidez-Romero Rene, Ramos-Jiménez Arnulfo
Departamento de Ciencias Químico Biológicas, Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, Ciudad Juárez, Chihuahua, México.
Departamento de Ciencias de la Salud, Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, Ciudad Juárez, Chihuahua, México.
BMJ Open. 2017 Jun 23;7(6):e013744. doi: 10.1136/bmjopen-2016-013744.
In order to reduce cardiovascular disease risk factors, a healthy diet must include dietary antioxidants from different sources (eg, ) and regular practice of exercise should be promoted. There is some evidence from animal studies that and exercise decrease cardiovascular disease risks factors. However, very few studies have proved the independent or synergistic effect of plus exercise in humans. This study attempts to address the independent and synergistic effects in overweight and obese subjects participating in a systematic physical exercise programme at moderate intensity on general fitness, plasma lipid profile and antioxidant capacity.
Using a randomised, double-blind, placebo-controlled, counterbalanced crossover study design, 80 healthy overweight and obese subjects will be evaluated during a 12-week isoenergetic diet accompanied by 4.5 g/day intake and/or a physical systematic exercise programme at moderate intensity. Body composition, oxygen uptake, heart rate, capillary blood lactate, plasma concentrations of triacylglycerols, total, low-density and high-density lipoprotein cholesterol, antioxidant status, lipid oxidation, protein carbonyls, superoxide dismutase, catalase, glutathione, glutathione peroxidase, glutathione reductase and paraoxonase will be assessed.
This study and all the procedures have been approved by the Universidad Autonoma de Ciudad Juarez Bioethics Committee. Findings will be disseminated through peer-reviewed journals, national and international conferences.
ClinicalTrials.gov: NCT02837666.
为降低心血管疾病风险因素，健康饮食必须包含来自不同来源的膳食抗氧化剂（例如， ），并应提倡定期进行体育锻炼。动物研究有一些证据表明， 与运动可降低心血管疾病风险因素。然而，极少有研究证实 加运动对人类的独立或协同作用。本研究旨在探讨参与中等强度系统体育锻炼计划的超重和肥胖受试者中， 与运动对总体健康状况、血浆脂质谱和抗氧化能力的独立及协同作用。
采用随机、双盲、安慰剂对照、平衡交叉研究设计，80名健康超重和肥胖受试者将在为期12周的等能量饮食期间接受评估，饮食中伴有每日4.5克 的摄入量和/或中等强度的系统体育锻炼计划。将评估身体成分、摄氧量、心率、毛细血管血乳酸、三酰甘油、总胆固醇、低密度和高密度脂蛋白胆固醇的血浆浓度、抗氧化状态、脂质氧化、蛋白质羰基、超氧化物歧化酶、过氧化氢酶、谷胱甘肽、谷胱甘肽过氧化物酶、谷胱甘肽还原酶和对氧磷酶。
本研究及所有程序均已获得华雷斯自治大学伦理委员会批准。研究结果将通过同行评审期刊、国内和国际会议进行传播。
ClinicalTrials.gov：NCT02837666。
