O'Brien Anthony Terrence, Torrealba Acosta Gabriel, Huerta Rodrigo, Thibaut Aurore
Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
Department of Medicine, Universidad Nacional Autonoma de Mexico, Coyoacan, Mexico.
BMJ Open. 2017 Jun 22;7(6):e015669. doi: 10.1136/bmjopen-2016-015669.
Dexterity is described as coordinated hand and finger movement for precision tasks. It is essential for day-to-day activities like computer use, writing or buttoning a shirt. Integrity of brain motor networks is crucial to properly execute these fine hand tasks. When these networks are damaged, interventions to enhance recovery are frequently accompanied by unwanted side effects or limited in their effect. Non-invasive brain stimulation (NIBS) are postulated to target affected motor areas and improve hand motor function with few side effects. However, the results across studies vary, and the current literature does not allow us to draw clear conclusions on the use of NIBS to promote hand function recovery. Therefore, we developed a protocol for a systematic review and meta-analysis on the effects of different NIBS technologies on dexterity in diverse populations. This study will potentially help future evidence-based research and guidelines that use these NIBS technologies for recovering hand dexterity.
This protocol will compare the effects of active versus sham NIBS on precise hand activity. Records will be obtained by searching relevant databases. Included articles will be randomised clinical trials in adults, testing the therapeutic effects of NIBS on continuous dexterity data. Records will be studied for risk of bias. Narrative and quantitative synthesis will be done.
No private health information is included; the study is not interventional. Ethical approval is not required. The results will be reported in a peer-review journal.
PROSPERO International prospective register of systematic reviews registration number: CRD42016043809.
灵活性被描述为手部和手指为完成精确任务而进行的协调运动。它对于诸如使用电脑、写作或扣衬衫纽扣等日常活动至关重要。大脑运动网络的完整性对于正确执行这些精细的手部任务至关重要。当这些网络受损时，促进恢复的干预措施常常伴随着不良副作用或效果有限。非侵入性脑刺激（NIBS）被假定可针对受影响的运动区域并改善手部运动功能，且副作用较少。然而，各项研究的结果不尽相同，当前的文献并不允许我们就使用NIBS促进手部功能恢复得出明确结论。因此，我们制定了一项方案，用于对不同NIBS技术对不同人群灵活性的影响进行系统评价和荟萃分析。这项研究可能会有助于未来基于证据的研究以及使用这些NIBS技术恢复手部灵活性的指南。
本方案将比较主动NIBS与假NIBS对精确手部活动的影响。通过检索相关数据库获取记录。纳入的文章将为针对成年人的随机临床试验，测试NIBS对连续灵活性数据的治疗效果。将研究记录的偏倚风险。将进行叙述性和定量综合分析。
不包含私人健康信息；该研究并非干预性研究。无需伦理批准。研究结果将在同行评审期刊上发表。
PROSPERO国际前瞻性系统评价注册库注册号：CRD42016043809。
