Deutschman C S, Haines S J
Neurosurgery. 1985 Sep;17(3):510-7. doi: 10.1227/00006123-198509000-00021.
Seizures complicate many neurosurgical diseases and, in many situations, their prevention is desirable. In an attempt to arrive at a rational approach to the purely prophylactic administration of anticonvulsants, existing data pertaining to four topics were examined: the danger posed by a single seizure, the incidence of seizures in a given disease state, the ability of anticonvulsant medication to prevent seizures, and the risks and benefits associated with pharmacological intervention. In general, where the risk of seizure exceeds 10 to 15% or where a single seizure may have disastrous consequences, anticonvulsant prophylaxis is recommended.
癫痫发作会使许多神经外科疾病复杂化，并且在许多情况下，预防癫痫发作是可取的。为了找到一种合理的方法来进行抗惊厥药物的单纯预防性给药，我们研究了与四个主题相关的现有数据：单次癫痫发作所带来的危险、特定疾病状态下癫痫发作的发生率、抗惊厥药物预防癫痫发作的能力以及药物干预相关的风险和益处。一般来说，当癫痫发作风险超过10%至15%，或者单次癫痫发作可能产生灾难性后果时，建议进行抗惊厥药物预防。
