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[新疆维吾尔自治区喀什地区维吾尔族人群血脂异常及血脂正常水平的患病率]

[Prevalence of dyslipidemia and normal blood lipids level in Uygur population in Kashgar area of Xinjiang Uygur Autonomous Region].

作者信息

Zhang Z B, Xue Z X, Wu X J, Wang T M, Li Y H, Song X L, Chao X F, Wang G, Nazibam Nurmamat, Ayxamgul Bawudun, Gulbahar Elyas, Zhou Z Y, Sun B S, Wang Y Z, Wang M

机构信息

Office of Director, Guangzhou Center for Disease Control and Prevention, Guangzhou, 510440 China.

Immunization Programme Section, Shufu Center for Disease Control and Prevention, Kashgar 844100, China.

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 2017 Jun 10;38(6):702-708. doi: 10.3760/cma.j.issn.0254-6450.2017.06.003.

Abstract

To understand the prevalence of dyslipidemia and normal blood lipids level in Uygur diabetes patients in Kashgar prefecture in southern area of Xinjiang. A total of 5 078 local residents aged ≥18 years (42.56 were men) selected through cluster random sampling in Kashgar were surveyed by means of questionnaire survey, physical examination and laboratory test, and 521 diabetes patients were screened. The overall prevalence of dyslipidemia in diabetes patients was 59.50 (310/521) with adjusted rate as 49.39. Age ≥65 years, overweight, obesity and abdominal obesity increased the risk for dyslipidemia by 0.771 times (95: 1.015-3.088), 1.132 times (95: 1.290-3.523), 1.688 times (95: 1.573-4.592) and 0.801 times (95: 1.028-3.155) respectively. Compared with males, female was a protective factor for dyslipidemia (=0.507, 95: 0.334-0.769). The overall normal rate of blood lipids level including total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) for type 2 diabetes patients was 11.13. Female, higher BMI and abdominal obesity were the factors influencing the overall normal blood lipids level. The normal rate of LDL-C level decreased with increase of age, BMI and waist circumferences (trend test (2)=18.049, <0.001; trend test (2)=10.582, =0.001; (2)=19.081, <0.001), but increased with educational level (trend test (2)=9.764, =0.002). The prevalence of dyslipidemia in Uygur diabetes patients in Kashgar was high, however, the overall normal rate of blood lipid level was relatively low. Obesity was the most important risk factor for dyslipidemia in this area. More attention should be paid to dyslipidemia prevention in women.

摘要

了解新疆南部喀什地区维吾尔族糖尿病患者血脂异常及血脂正常水平的流行情况。通过整群随机抽样选取喀什地区≥18岁的5078名当地居民(男性占42.56),采用问卷调查、体格检查和实验室检测的方法进行调查,筛查出521例糖尿病患者。糖尿病患者血脂异常的总体患病率为59.50(310/521),校正率为49.39。年龄≥65岁、超重、肥胖和腹型肥胖使血脂异常风险分别增加0.771倍(95%CI:1.015 - 3.088)、1.132倍(95%CI:1.290 - 3.523)、1.688倍(95%CI:1.573 - 4.592)和0.801倍(95%CI:1.028 - 3.155)。与男性相比,女性是血脂异常的保护因素(P = 0.507,95%CI:0.334 - 0.769)。2型糖尿病患者总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL - C)和低密度脂蛋白胆固醇(LDL - C)血脂水平的总体正常率为11.13。女性、较高的BMI和腹型肥胖是影响血脂总体正常水平的因素。LDL - C水平的正常率随年龄、BMI和腰围的增加而降低(趋势检验χ² = 18.049,P < 0.001;趋势检验χ² = 10.582,P = 0.001;χ² = 19.081,P < 0.001),但随受教育程度的提高而增加(趋势检验χ² = 9.764,P = 0.002)。喀什地区维吾尔族糖尿病患者血脂异常患病率高,但血脂水平总体正常率相对较低。肥胖是该地区血脂异常最重要的危险因素。应更加关注女性血脂异常的预防。

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