Zhang Yang, Wu Jiayong, Wu Wenbo, Liu Renyuan, Pang Lingen, Guan Dening, Xu Yun
a Department of Neurology , Drum Tower Hospital , Medical School of Nanjing University , Nanjing , China.
b Department of Medical Imaging , Drum Tower Hospital , Medical School of Nanjing University , Nanjing , China.
Int J Neurosci. 2018 Jan;128(1):25-31. doi: 10.1080/00207454.2017.1347170. Epub 2017 Jul 18.
Apathy is a common non-motor symptom in Parkinson's disease (PD), but little is known about apathy and white matter (WM) change. In this study, we investigated whether fractional anisotropy (FA) of the WM can distinguish apathetic patients from non-apathetic PD patients, and whether the FA value correlates with the severity of apathy in PD.
Thirty-nine PD patients participated in our study, of which 18 participants were with apathy symptom, and 21 without apathy symptom. Diffusion tensor imaging was performed on all the subjects.
Compared to non-apathetic PD patients, the apathetic group had reduced FA values in the genu and body of corpus callosum, bilateral anterior corona radiata, left superior corona radiata and left cingulum. Furthermore, in these WM regions, the FA values were negatively correlated with the Lille Apathy Rating Scale scores in apathetic subjects.
The WM change is associated with apathy in PD patients. In addition, the FA values of specific regions of WM could be a promising marker to predict the severity of apathy.
冷漠是帕金森病（PD）常见的非运动症状，但关于冷漠与白质（WM）变化的了解甚少。在本研究中，我们调查了WM的分数各向异性（FA）是否能够区分有冷漠症状的PD患者和无冷漠症状的PD患者，以及FA值是否与PD患者的冷漠严重程度相关。
39名PD患者参与了我们的研究，其中18名参与者有冷漠症状，21名无冷漠症状。对所有受试者进行了扩散张量成像。
与无冷漠症状的PD患者相比，有冷漠症状的组在胼胝体膝部和体部、双侧放射冠前部、左侧放射冠上部和左侧扣带束的FA值降低。此外，在这些WM区域，FA值与有冷漠症状受试者的里尔冷漠评定量表得分呈负相关。
WM变化与PD患者的冷漠有关。此外，WM特定区域的FA值可能是预测冷漠严重程度的一个有前景的标志物。
