Li Jing, Wang Jing, Zhong Yan, Guo Ruixia, Chu Danxia, Qiu Haifeng, Yuan Zhongfu
Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052 China.
Department of Obstetrics and Gynecology, Yantai Yuhuangding Hospital Affiliated to the Medical College of Qingdao University, Yantai, 264000 China.
Cancer Cell Int. 2017 Jun 21;17:65. doi: 10.1186/s12935-017-0434-6. eCollection 2017.
Long non-coding RNAs (lncRNAs) play critical roles in the initiation and progression of human cancers. HOX transcript antisense RNA () is an lncRNA localized to the mammalian gene cluster; it can interact with polycomb repressive complex 2 and the lysine-specific histone demethylase/CoREST/REST complex, and it manipulates the expression of various genes. promotes tumor invasion and metastasis by silencing tumor suppressors, and activating oncogenes and signaling pathways. is deregulated in many human cancers; despite its critical roles in health and disease, the underlying mechanisms governing function are unknown. In this review, we summarize the recent findings on the roles of in gynecologic cancers.
长链非编码RNA（lncRNAs）在人类癌症的发生和发展中起着关键作用。HOX转录本反义RNA（）是一种定位于哺乳动物基因簇的lncRNA；它可以与多梳抑制复合物2以及赖氨酸特异性组蛋白去甲基化酶/CoREST/REST复合物相互作用，并调控多种基因的表达。通过沉默肿瘤抑制因子、激活癌基因和信号通路促进肿瘤侵袭和转移。在许多人类癌症中表达失调；尽管其在健康和疾病中起着关键作用，但其发挥功能的潜在机制尚不清楚。在本综述中，我们总结了关于在妇科癌症中作用的最新研究发现。
