: a key regulator in gynecologic cancers.

Long non-coding RNAs (lncRNAs) play critical roles in the initiation and progression of human cancers. HOX transcript antisense RNA () is an lncRNA localized to the mammalian gene cluster; it can interact with polycomb repressive complex 2 and the lysine-specific histone demethylase/CoREST/REST complex, and it manipulates the expression of various genes. promotes tumor invasion and metastasis by silencing tumor suppressors, and activating oncogenes and signaling pathways. is deregulated in many human cancers; despite its critical roles in health and disease, the underlying mechanisms governing function are unknown. In this review, we summarize the recent findings on the roles of in gynecologic cancers.