Lacerda Eliana M, Bowman Erinna W, Cliff Jacqueline M, Kingdon Caroline C, King Elizabeth C, Lee Ji-Sook, Clark Taane G, Dockrell Hazel M, Riley Eleanor M, Curran Hayley, Nacul Luis
CureME Research Team, International Centre for Evidence in Disability (ICED), Department of Clinical Research (CRD), Faculty of Infectious and Tropical Diseases at the London School of Hygiene & Tropical Medicine, Keppel St, London WC1E 7HT, UK.
Department of Immunology & Infection, Faculty of Infectious and Tropical Diseases at the London School of Hygiene & Tropical Medicine, Keppel St, London WC1E 7HT, UK.
Open J Bioresour. 2017;4. doi: 10.5334/ojb.28. Epub 2017 Feb 20.
The UK ME/CFS Biobank was launched in August 2011 following extensive consultation with professionals and patient representatives. The bioresource aims to enhance research on myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), related to pathophysiology, biomarkers and therapeutic approaches. The cohort includes 18-60 year olds, encompassing 284 clinically-confirmed ME/CFS cases, 60 neurologist-diagnosed multiple sclerosis (MS) cases, and 135 healthy individuals. The Biobank contains blood samples, aliquoted into serum, plasma, peripheral blood mononuclear cells (PBMC), red blood cells/granulocyte pellet, whole blood, and RNA (totalling 29,863 aliquots). Extensive dataset (700 clinical and socio-demographic variables/participant) enables comprehensive phenotyping. Potential reuse is conditional to ethical approval.
英国肌痛性脑脊髓炎/慢性疲劳综合征生物样本库于2011年8月启动，此前与专业人士和患者代表进行了广泛协商。该生物资源旨在加强对肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）在病理生理学、生物标志物和治疗方法方面的研究。该队列包括18至60岁的人群，其中有284例临床确诊的ME/CFS病例、60例经神经科医生诊断的多发性硬化症（MS）病例以及135名健康个体。生物样本库包含血液样本，被分装成血清、血浆、外周血单核细胞（PBMC）、红细胞/粒细胞沉淀、全血和RNA（共29,863份分装样本）。广泛的数据集（每个参与者有700个临床和社会人口统计学变量）有助于进行全面的表型分析。潜在的再利用需经伦理批准。
