Xin Xiu-Lan, Zhao Xin-Yu, Huo Xiao-Kui, Tian Xiang-Ge, Sun Cheng-Peng, Zhang Hou-Li, Tian Yan, Liu Yong, Wang Xun
a College of Bioengineering , Beijing Polytechnic , Beijing , China.
b Key Laboratory of Metabolism and Transport of Liaoning, College of Pharmacy , Dalian Medical University , Dalian , China.
Nat Prod Res. 2018 Jan;32(2):189-194. doi: 10.1080/14786419.2017.1344660. Epub 2017 Jun 26.
Two new protostane-type triterpenoids, 17-epi alisolide (1) and 24-epi alismanol D (2), were isolated from Alisma orientalis together with one known compound. Their structural elucidations were conducted by NMR, UV and HRESIMS spectroscopic analyses, and comparison with the literature data. All the isolated compounds were evaluated for inhibitory effects on HCE-2. Compound 2 displayed moderate inhibitory activity against HCE-2 with IC value of 23.1 μM.
从泽泻中分离出两种新的原萜烷型三萜化合物，17-表泽泻醇内酯（1）和24-表泽泻醇D（2），以及一种已知化合物。通过核磁共振（NMR）、紫外（UV）和高分辨电喷雾电离质谱（HRESIMS）光谱分析，并与文献数据进行比较，对它们的结构进行了鉴定。对所有分离出的化合物进行了对人角膜上皮细胞-2（HCE-2）的抑制作用评估。化合物2对HCE-2表现出中等抑制活性，IC值为23.1 μM。
