围生期获得性HIV与HBV合并感染中的肝细胞癌：一例报告

Hepatocellular Carcinoma in Perinatally Acquired HIV and HBV Coinfection: A Case Report.

作者信息

Seers Timothy, Sarker Debashis, Ross Paul, Heaton Nigel, Suddle Abid, Lyall Hermione, Tudor-Williams Gareth, Fidler Sarah, Foster Caroline

机构信息

From the *Imperial College London, London, United Kingdom; †King's College Hospital, London, United Kingdom; ‡King's College London, London, United Kingdom; and §Imperial College Healthcare NHS Trust, London, United Kingdom.

出版信息

Pediatr Infect Dis J. 2017 Dec;36(12):1156-1158. doi: 10.1097/INF.0000000000001662.

DOI:10.1097/INF.0000000000001662

PMID:28650418

Abstract

This report describes a case of hepatocellular carcinoma in an adolescent with perinatally acquired HIV and hepatitis B virus coinfection, arising despite more than a decade of suppressive antiretroviral therapy for both HIV and hepatitis B virus. This case raises important questions regarding optimal hepatocellular carcinoma screening in this high-risk group and the oncogenic potential of even very well-controlled viral infection.

摘要

本报告描述了一例青少年肝细胞癌病例，该青少年围产期感染了HIV和乙肝病毒，尽管对HIV和乙肝病毒进行了十多年的抑制性抗逆转录病毒治疗，但仍发生了肝细胞癌。该病例引发了关于这一高危人群最佳肝细胞癌筛查以及即使病毒感染得到很好控制时的致癌潜力的重要问题。