Institute of Genetic Medicine, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, United Kingdom.
Institute of Genetic Medicine, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, United Kingdom; Freeman Hospital, Newcastle upon Tyne NHS Foundation Trust, Freeman Road, High Heaton, Newcastle upon Tyne NE7 7DN, United Kingdom.
Exp Gerontol. 2018 Aug;109:38-46. doi: 10.1016/j.exger.2017.06.014. Epub 2017 Jun 23.
Prevalence of age-associated cardiovascular diseases (CVD) has dramatically increased as a result of improvements in life expectancy. Chronic inflammation is a shared pathophysiological feature of age-associated CVDs, indicating a role for the immune system in the onset and development of CVDs. Indeed, ageing elicits profound changes in both the cardiovascular and immune system, especially in the T cell compartment. Although such changes have been well described at the cellular level, the molecular mechanisms underlying immune-mediated cardiovascular ageing remain largely unexplored. Non-coding RNAs (ncRNAs) comprise a heterogeneous family of RNA transcripts that regulate gene expression at the epigenetic, transcriptional, post-transcriptional, and post-translational levels. Non-coding RNAs have recently emerged as master modulators of T cell immunity. In this review, the state-of-the-art knowledge on ncRNA regulatory effects over T cell differentiation, function, and ageing in the context of age-associated CVDs, such as atherosclerosis, acute coronary syndromes, and heart failure, is discussed.
随着预期寿命的提高，与年龄相关的心血管疾病（CVD）的患病率显著增加。慢性炎症是与年龄相关的 CVD 的共同病理生理特征，表明免疫系统在 CVD 的发生和发展中起作用。事实上，衰老会引起心血管系统和免疫系统的深刻变化，尤其是 T 细胞区室。尽管这些变化在细胞水平上已经得到了很好的描述，但免疫介导的心血管衰老的分子机制在很大程度上仍未得到探索。非编码 RNA（ncRNA）是一类异质的 RNA 转录物家族，可在表观遗传、转录、转录后和翻译后水平上调节基因表达。非编码 RNA 最近已成为 T 细胞免疫的主要调节因子。在这篇综述中，讨论了在与年龄相关的 CVD（如动脉粥样硬化、急性冠状动脉综合征和心力衰竭）背景下，ncRNA 对 T 细胞分化、功能和衰老的调控作用的最新知识。
