Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, Qingdao Medical College, Qingdao University, Qingdao, 266021, China.
School of Basic Medical Sciences, Qingdao Medical College, Qingdao University, Qingdao, 266071, China.
J Mol Med (Berl). 2023 May;101(5):501-526. doi: 10.1007/s00109-023-02305-8. Epub 2023 Apr 4.
Cardiovascular disease (CVD) is the leading cause of disease-related death worldwide and a significant obstacle to improving patients' health and lives. Mitochondria are core organelles for the maintenance of myocardial tissue homeostasis, and their impairment and dysfunction are considered major contributors to the pathogenesis of various CVDs, such as hypertension, myocardial infarction, and heart failure. However, the exact roles of mitochondrial dysfunction involved in CVD pathogenesis remain not fully understood. Non-coding RNAs (ncRNAs), particularly microRNAs, long non-coding RNAs, and circular RNAs, have been shown to be crucial regulators in the initiation and development of CVDs. They can participate in CVD progression by impacting mitochondria and regulating mitochondrial function-related genes and signaling pathways. Some ncRNAs also exhibit great potential as diagnostic and/or prognostic biomarkers as well as therapeutic targets for CVD patients. In this review, we mainly focus on the underlying mechanisms of ncRNAs involved in the regulation of mitochondrial functions and their role in CVD progression. We also highlight their clinical implications as biomarkers for diagnosis and prognosis in CVD treatment. The information reviewed herein could be extremely beneficial to the development of ncRNA-based therapeutic strategies for CVD patients.
心血管疾病（CVD）是全球范围内导致疾病相关死亡的主要原因，也是改善患者健康和生活的重大障碍。线粒体是维持心肌组织内稳态的核心细胞器，其损伤和功能障碍被认为是各种 CVD 发病机制的主要因素，如高血压、心肌梗死和心力衰竭。然而，线粒体功能障碍在 CVD 发病机制中的确切作用仍不完全清楚。非编码 RNA（ncRNA），特别是 microRNA、长非编码 RNA 和环状 RNA，已被证明是 CVD 发生和发展的关键调节因子。它们可以通过影响线粒体和调节与线粒体功能相关的基因和信号通路来参与 CVD 的进展。一些 ncRNA 也作为 CVD 患者的诊断和/或预后生物标志物以及治疗靶点具有很大的潜力。在这篇综述中，我们主要关注 ncRNA 调节线粒体功能的潜在机制及其在 CVD 进展中的作用。我们还强调了它们作为 CVD 治疗中诊断和预后生物标志物的临床意义。本文综述的信息对开发基于 ncRNA 的 CVD 患者治疗策略非常有益。
