Ahmadi Peni, Haruyama Takahiro, Kobayashi Nobuyuki, de Voogd Nicole Joy, Tanaka Junichi
Department of Chemistry, Biology and Marine Science, University of the Ryukyus.
AVSS Co., Ltd.
Chem Pharm Bull (Tokyo). 2017 Sep 1;65(9):874-877. doi: 10.1248/cpb.c17-00297. Epub 2017 Jun 23.
Extracts of the sponge Hyattella aff. intestinalis showed moderate inhibition against adenovirus. Chromatographic separation of the extracts followed by analysis of spectroscopic data allowed us to elucidate the structures of three new metabolites as 2α-hydroxyspongia-13(16),14-diene-3-one (4), 3β-hydroxyspongia-13(16),14-diene-2-one (7), and 2α,3α-diacetoxy-17,19-dihydroxyspongia-13(16),14-diene (8) and to identify six known ones 1-3, 5, 6 and 9. Among the molecules, compounds 1 and 3 showed antiviral activity at IC 17.0 and 52.0 µM.
海绵动物Hyattella aff. intestinalis的提取物对腺病毒显示出中等程度的抑制作用。对提取物进行色谱分离并分析光谱数据后，我们阐明了三种新代谢产物的结构，分别为2α-羟基海绵-13(16),14-二烯-3-酮（4）、3β-羟基海绵-13(16),14-二烯-2-酮（7）和2α,3α-二乙酰氧基-17,19-二羟基海绵-13(16),14-二烯（8），并鉴定出六种已知的代谢产物1 - 3、5、6和9。在这些分子中，化合物1和3在IC为17.0和52.0 μM时显示出抗病毒活性。
