来自海绵可变硬皮海绵的两种呋喃甾萜类化合物。

Ahmadi Peni, Higashi Masahiro, Voogd Nicole J de, Tanaka Junichi

Department of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan.

Naturalis Biodiversity Center, P.O. Box 9517, 2300 RA Leiden, The Netherlands.

Mar Drugs. 2017 Aug 10;15(8):249. doi: 10.3390/md15080249.

Two new sesterterpenoids, and 2, were isolated from the sponge . Their planar structures were characterized with spectroscopic analyses. The sole chiral center of compound was elucidated as 12 by comparing observed and calculated optical rotation values. The configurations of compound 2 were determined by NMR and electronic circular dichroism (ECD) studies. Furthermore, compound 2 showed cytotoxicity at IC 1.0 µM against NBT-T2 cells.

从海绵中分离出两种新的倍半萜化合物，即化合物1和化合物2。通过光谱分析对它们的平面结构进行了表征。通过比较观察到的和计算得到的旋光值，确定化合物1的唯一手性中心为12。通过核磁共振（NMR）和电子圆二色光谱（ECD）研究确定了化合物2的构型。此外，化合物2对NBT-T2细胞显示出细胞毒性，其半数抑制浓度（IC）为1.0 μM。