Jin Tianyun, Li Pinglin, Wang Cili, Tang Xuli, Yv Xiaoli, Li Kai, Luo Lianzhong, Ou Huilong, Li Guoqiang
D Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy Department, Ocean University of China, Qingdao, People's Republic of China.
Laboratory of Marine Drugs and Biological Products, National Laboratory for Marine Science and Technology, Qingdao, People's Republic of China.
Nat Prod Res. 2023 Jan;37(2):216-226. doi: 10.1080/14786419.2021.1961137. Epub 2021 Aug 4.
2,3,19-Triacetoxy-17-hydroxyspongia-13(16),14-diene (), a novel acetoxy diterpenoid, and 18-nor-2,17-hydroxyspongia-1,4,13(16),14-quaien-3-one (), belonging to the rare 18-nor-spongian carbon skeleton, together with six related known metabolites (‒), were isolated from the aquaculture Linnaeus, 1759. Their structures were elucidated by comprehensive spectroscopic analysis, quantum chemical calculation of NMR parameters, and electronic circular dichroism (ECD). Compounds , , and exhibited moderate inhibition against STAT3/NF-B, HIF-1, Wnt signalling pathways. Compounds , , and showed cytotoxicity activities against K562 cell line with IC values of 7.3, 3.5, and 6.4 M, respectively.
2,3,19-三乙酰氧基-17-羟基海绵-13(16),14-二烯（），一种新型的乙酰氧基二萜类化合物，以及18-降-2,17-羟基海绵-1,4,13(16),14-四烯-3-酮（），属于罕见的18-降海绵烷碳骨架，与六种相关的已知代谢产物（‒）一起，从养殖的1759年林奈的物种中分离得到。通过综合光谱分析、核磁共振参数的量子化学计算以及电子圆二色光谱（ECD）对它们的结构进行了阐明。化合物、和对STAT3/NF-κB、HIF-1、Wnt信号通路表现出中等程度的抑制作用。化合物、和对K562细胞系显示出细胞毒性活性，IC50值分别为7.3、3.5和6.4 μM。
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