Department of Chemistry, Tarbiat Modares University, Tehran, P.O. Box 14115-175, Iran.
Mol Divers. 2017 Nov;21(4):849-854. doi: 10.1007/s11030-017-9761-8. Epub 2017 Jun 26.
An efficient method for the synthesis of oxo-thioxo[3.3.3]propellanes via reaction of dithiocarbamates, generated from primary amines and carbon disulfide, with the Knoevenagel adduct resulting from ninhydrin and malononitrile in [Formula: see text] at room temperature is described. These transformations are highlighted by their chemo- and regioselectivity, lack of activator or metal promoters, inert atmosphere, and formation of four new bonds in one operation.
一种通过反应生成的 dithiocarbamates 的合成氧代硫代[3.3.3]丙环的有效方法，由伯胺和二硫化碳生成，与[化学式：见文本]中由水合茚满和丙二腈生成的 Knoevenagel 加合物反应，在室温下进行。这些转化的特点是化学和区域选择性、缺乏活化剂或金属促进剂、惰性气氛以及在一次操作中形成四个新键。
