McKee K T, Kim G R, Green D E, Peters C J
J Med Virol. 1985 Oct;17(2):107-17. doi: 10.1002/jmv.1890170203.
The Hantaan virus suckling mouse model was examined to delineate virologic and histopathologic characteristics of infection at the organ level. Viral antigen and infectious virus were detected in all organs examined, with highest titers achieved in brain, lung, and kidney. A constellation of histologic lesions was identified in brain (diffuse meningoencephalitis with bilaterally symmetrical thalamic necrosis), liver (pericholangiohepatitis), lung (pneumonitis), and spleen (lymphoid hyperplasia); this tetrad is apparently unique to this model system. The chronology of clinical, virologic, serologic, and pathologic findings in Hantaan-infected newborn mice suggests an immune-mediated mechanism in disease pathogenesis.
对汉坦病毒乳鼠模型进行了研究，以描绘器官水平感染的病毒学和组织病理学特征。在所有检测的器官中均检测到病毒抗原和传染性病毒，其中脑、肺和肾中的滴度最高。在脑（弥漫性脑膜脑炎伴双侧对称性丘脑坏死）、肝（胆管周围性肝炎）、肺（肺炎）和脾（淋巴组织增生）中发现了一组组织学病变；这一四联征在该模型系统中显然是独特的。汉坦病毒感染的新生小鼠的临床、病毒学、血清学和病理学发现的时间顺序表明疾病发病机制中存在免疫介导机制。
