建立 IONP 定量与回声和无回声 MR 弛豫映射的重叠。
Establishing the overlap of IONP quantification with echo and echoless MR relaxation mapping.
机构信息
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.
Department of Chemistry, University of Minnesota, Minneapolis, Minnesota, USA.
出版信息
Magn Reson Med. 2018 Mar;79(3):1420-1428. doi: 10.1002/mrm.26800. Epub 2017 Jun 26.
PURPOSE
Iron-oxide nanoparticles (IONPs) have shown tremendous utility for enhancing image contrast and delivering targeted therapies. Quantification of IONPs has been demonstrated at low concentrations with gradient echo (GRE) and spin echo (SE), and at high concentrations with echoless sequences such as swept imaging with Fourier transform (SWIFT). This work examines the overlap of IONP quantification with GRE, SE, and SWIFT.
METHODS
The limit of quantification of GRE, SE, inversion-recovery GRE, and SWIFT sequences was assessed using IONPs at a concentration range of 0.02 to 89.29 mM suspended in 1% agarose. Empirically derived limits of quantification were compared with International Union of Pure and Applied Chemistry definitions. Both commercial and experimental IONPs were used.
RESULTS
All three IONPs assessed demonstrated an overlap of concentration quantification with GRE, SE, and SWIFT sequences. The largest dynamic range observed was 0.004 to 35.7 mM with Feraheme.
CONCLUSIONS
The metrics established allow upper and lower quantitative limitations to be estimated given the relaxivity characteristics of the IONP and the concentration range of the material to be assessed. The methods outlined in this paper are applicable to any pulse sequence, IONP formulation, and field strength. Magn Reson Med 79:1420-1428, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
目的
氧化铁纳米颗粒（IONP）在增强图像对比度和提供靶向治疗方面显示出巨大的应用潜力。已经证明，在低浓度下可以使用梯度回波（GRE）和自旋回波（SE）对 IONP 进行定量，而在高浓度下可以使用无回波序列（如傅里叶变换的扫频成像（SWIFT））进行定量。本研究探讨了 GRE、SE 和 SWIFT 与 IONP 定量的重叠。
方法
使用浓度范围为 0.02 至 89.29 mM 的悬浮在 1%琼脂糖中的 IONP 评估 GRE、SE、反转恢复 GRE 和 SWIFT 序列的定量下限。经验推导的定量下限与国际纯粹与应用化学联合会的定义进行了比较。使用了商业和实验性的 IONP。
结果
评估的三种 IONP 均显示与 GRE、SE 和 SWIFT 序列的浓度定量有重叠。使用 Feraheme 观察到的最大动态范围为 0.004 至 35.7 mM。
结论
给定 IONP 的弛豫率特征和待评估材料的浓度范围，可以估计出定量的上下限。本文中概述的方法适用于任何脉冲序列、IONP 配方和磁场强度。磁共振医学 79:1420-1428, 2018。© 2017 国际磁共振学会。
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