细胞外囊泡与系统生物学和计算建模在心脏修复中的应用。
Extracellular Vesicles and the Application of System Biology and Computational Modeling in Cardiac Repair.
机构信息
From the Center for Translational Medicine (V.N.S.G., R.K.).
Lewis Katz School of Medicine, Temple University, Philadelphia, PA; Wallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta (F.S.-T., M.E.D.).
出版信息
Circ Res. 2018 Jul 6;123(2):188-204. doi: 10.1161/CIRCRESAHA.117.311215.
Abstract
Recent literature suggests that extracellular vesicles (EVs), secreted from most cells and containing cell-specific cargo of proteins, lipids, and nucleic acids, are major driver of intracellular communication in normal physiology and pathological conditions. The recent evidence on stem/progenitor cell EVs as potential therapeutic modality mimicking their parental cell function is exciting because EVs could possibly be used as a surrogate for the stem cell-based therapy, and this regimen may overcome certain roadblocks identified with the use of stem/progenitor cell themselves. This review provides a comprehensive update on our understanding on the role of EVs in cardiac repair and emphasizes the applications of stem/progenitor cell-derived EVs as therapeutics and discusses the current challenges associated with the EV therapy.
摘要
最近的文献表明，细胞外囊泡（EVs）由大多数细胞分泌，包含蛋白质、脂质和核酸等细胞特异性货物，是正常生理和病理条件下细胞内通讯的主要驱动因素。最近关于干细胞/祖细胞 EVs 作为潜在治疗方式的证据令人兴奋，因为 EVs 可以作为基于干细胞治疗的替代物，并且这种方案可能克服了使用干细胞/祖细胞本身所遇到的某些障碍。本文综述了我们对 EV 在心脏修复中的作用的理解，并强调了干细胞/祖细胞衍生的 EVs 在治疗中的应用，同时讨论了与 EV 治疗相关的当前挑战。
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本文引用的文献
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