Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.
Neuromodulation. 2018 Feb;21(2):191-196. doi: 10.1111/ner.12625. Epub 2017 Jun 27.
Create a software tool to facilitate tractography-based deep brain stimulation (DBS) electrode targeting within the patient-specific stereotactic coordinate system used in the operating room.
StimVision was developed with Visualization Toolkit libraries and integrates four major components: 1) medical image visualization, 2) tractography visualization, 3) DBS electrode positioning, and 4) DBS activation volume calculation with tractography intersection.
Initial applications of StimVision are focused on the study of subcallosal cingulate (SCC) DBS for the treatment of depression. Retrospective modeling results on SCC DBS have suggested that direct stimulation of a specific collection of tractographic pathways are necessary for therapeutic benefit; thereby creating a tractography-based DBS surgical targeting hypotheses. StimVision is the tool we created to facilitate prospective clinical evaluation of that hypothesis.
Retrospective tractography-based analyses are common in DBS research; however, intraoperative software tools for interactive selection of a tractography-based DBS target are not readily available. StimVision provides an academic research tool to assist clinical implementation of new DBS targeting strategies and postoperative evaluation of targeting outcome.
创建一个软件工具，以在手术中使用的患者特定立体定向坐标系内方便基于束流追踪的深部脑刺激（DBS）电极定位。
StimVision 是使用可视化工具包库开发的，它集成了四个主要组件：1）医学图像可视化，2）束流追踪可视化，3）DBS 电极定位，以及 4）通过束流追踪交叉计算 DBS 激活体积。
StimVision 的初步应用集中在研究治疗抑郁症的扣带回下纵束（SCC）DBS。SCC DBS 的回顾性建模结果表明，直接刺激特定的束流追踪路径集合对于治疗效果是必要的；从而产生了基于束流追踪的 DBS 手术靶点假说。StimVision 是我们创建的工具，用于促进该假说的前瞻性临床评估。
基于束流追踪的回顾性分析在 DBS 研究中很常见；然而，用于交互式选择基于束流追踪的 DBS 目标的术中软件工具并不常见。StimVision 提供了一个学术研究工具，用于辅助新的 DBS 靶向策略的临床实施和术后靶向效果的评估。
