Yang L, Teng Y, Han T-P, Li F-G, Yue W-T, Wang Z-T
Department of Thoracic Surgery, Beijing Chest Hospital, , , China.
Department of Cellular and Molecular Biology, Beijing Chest Hospital, , , China.
Genet Mol Res. 2017 Jun 20;16(2):gmr-16-02-gmr.16029617. doi: 10.4238/gmr16029617.
Lung cancer is the leading cause of cancer death in men and the second leading cause of cancer death in women worldwide. Fascin-1 and laminin-5 were associated with the invasiveness and prognoses of several cancers. The expression and the serum levels of fascin-1 and laminin-5 in patients with non-small cell lung cancer (NSCLC) were analyzed in this study. The expression of fascin-1 and laminin-5 were examined in 378 patients and their serum level was measured in 154 patients. The health of all patients was followed post-surgery. The expression of fascin-1 (P = 0.000) and lanminin-5 (P = 0.001) and the serum levels of fascin-1 (P = 0.015) and laminin-5 (P = 0.046) were related to the relapse of patients with NSCLC. Both serum levels and expression of fascin-1 and laminin-5 can be used to effectively evaluate the prognoses of patients with NSCLC.
肺癌是全球男性癌症死亡的主要原因，也是女性癌症死亡的第二大原因。Fascin-1和层粘连蛋白-5与几种癌症的侵袭性和预后相关。本研究分析了非小细胞肺癌（NSCLC）患者中Fascin-1和层粘连蛋白-5的表达及血清水平。检测了378例患者中Fascin-1和层粘连蛋白-5的表达，并测定了154例患者的血清水平。所有患者术后均进行随访。Fascin-1（P = 0.000）和层粘连蛋白-5（P = 0.001）的表达以及Fascin-1（P = 0.015）和层粘连蛋白-5（P = 0.046）的血清水平与NSCLC患者的复发有关。Fascin-1和层粘连蛋白-5的血清水平及表达均可有效评估NSCLC患者的预后。
