Zhang Yunxia, Liang Bin, Dong Hongying
Department of Respiratory, The 3rd Peoples' Hospital of Hangzhou City, Hangzhou Shi, Zhejiang, China.
J Cancer Res Ther. 2018;14(4):856-859. doi: 10.4103/jcrt.JCRT_732_17.
The aim of this study is to explore the expression of Fascin_1 protein in cancer tissues of patients with nonsmall cell lung cancer (NSCLC) and its relevance to patients' clinicopathologic features and prognosis.
Retrospective analysis was performed on 81 patients with NSCLC who were admitted to our hospital and received surgical treatment from February 2012 to March 2016. To analyze the correlation of Fascin_1 protein expression in cancer tissues with the clinicopathologic features and prognosis of the patients, the immuno-histochemical method was applied to examine Fascin_1 protein expression in cancer and normal paracarcinoma tissues of the included 81 NSCLC patients.
Fascin_1 protein was diffused in cancer tissues, and cancer cells surrounding the carcinoma lesions were strongly stained. The protein was mainly located on the cytoplast or membrane of positive cells and manifested as a focal or diffuse brown granular distribution. The negative, weakly positive, and strongly positive expression rates in cancer tissues were 23.5% (19/81), 35.8% (29/81), and 40.7% (33/81), respectively. The negative, weakly positive, and strongly positive expression rates in paracarcinoma tissues were 71.6% (58/81), 12.3% (10/81), and 16% (13/81), respectively. The difference was statistically significant (P < 0.05), and the positive expression rate of Fascin_1 in cancer tissues was significantly higher than that of in paracarcinoma tissues (P < 0.05). The positive expression of Fascin_1 in cancer tissues was significantly correlated with the neoplasm stage (P < 0.05) and mediastinal lymph node metastases (P < 0.05); however, it was not relevant to the patients' age, gender, tumor size, pathological type, tumor grading, or pleural effusion (P > 0.05). The median survival times for patients with positive Fascin_1 and negative Fascin_1 expression in cancer tissues were 26 and 44 months, respectively, indicating that the median survival time of the Fascin_1-positive group was significantly lower than that of in the Fascin_1-negative group (heart rate = 2.74, 95% confidence interval: 1.32-6.87, P < 0.05).
Fascin_1 protein expression in NSCLC tissues and normal paracarcinoma issues were different. Fascin_1 expression in cancer tissues was related to the poor prognosis of NSCLC patients.
本研究旨在探讨Fascin_1蛋白在非小细胞肺癌（NSCLC）患者癌组织中的表达情况及其与患者临床病理特征和预后的相关性。
对2012年2月至2016年3月期间我院收治并接受手术治疗的81例NSCLC患者进行回顾性分析。为分析癌组织中Fascin_1蛋白表达与患者临床病理特征及预后的相关性，采用免疫组织化学方法检测纳入研究的81例NSCLC患者癌组织及癌旁正常组织中Fascin_1蛋白的表达。
Fascin_1蛋白在癌组织中呈弥漫性分布，癌灶周围癌细胞呈强阳性染色。该蛋白主要位于阳性细胞的细胞质或细胞膜上，表现为局灶性或弥漫性棕色颗粒状分布。癌组织中阴性、弱阳性和强阳性表达率分别为23.5%（19/81）、35.8%（29/81）和40.7%（33/81）。癌旁组织中阴性、弱阳性和强阳性表达率分别为71.6%（58/81）、12.3%（10/81）和16%（13/81）。差异具有统计学意义（P<0.05），癌组织中Fascin_1的阳性表达率显著高于癌旁组织（P<0.05）。癌组织中Fascin_1的阳性表达与肿瘤分期（P<0.05）和纵隔淋巴结转移（P<0.05）显著相关；然而，与患者的年龄、性别、肿瘤大小、病理类型、肿瘤分级或胸腔积液无关（P>0.05）。癌组织中Fascin_1表达阳性和阴性的患者中位生存时间分别为26个月和44个月，表明Fascin_1阳性组的中位生存时间显著低于Fascin_1阴性组（心率=2.74，95%置信区间：1.32 - 6.87，P<0.05）。
NSCLC组织和癌旁正常组织中Fascin_1蛋白表达存在差异。癌组织中Fascin_1表达与NSCLC患者预后不良相关。
