Tian Yaohua, Xiang Xiao, Juan Juan, Sun Kexin, Song Jing, Cao Yaying, Hu Yonghua
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, No.38 Xueyuan Road, 100191 Beijing, China.
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, No.38 Xueyuan Road, 100191 Beijing, China.
Environ Pollut. 2017 Nov;230:227-233. doi: 10.1016/j.envpol.2017.06.029. Epub 2017 Jun 24.
Data on fine particulate matter (PM) in China were first announced in 2013. The primary objective of this study was to evaluate the acute effects of PM on asthma morbidity in Beijing, China. A total of 978,658 asthma hospital visits consisting of 928,607 outpatient visits, 40,063 emergency room visits and 9988 hospital admissions from January 1, 2010, to June 30, 2012, were identified from the Beijing Medical Claim Data for Employees. A generalized additive Poisson model was applied to explore the association between PM and health service use. The mean daily PM concentration was 99.5 μg/m with a range from 7.2 μg/m to 492.8 μg/m. Ambient PM concentration was significantly associated with increased use of asthma-related health services. Every 10 μg/m increase in PM concentration on the same day was significantly associated with a 0.67% (95% CI, 0.53%-0.81%), 0.65% (95% CI, 0.51%-0.80%), and 0.49% (95% CI, 0.35%-0.64%) increase in total hospital visits, outpatient visits and emergency room visits, respectively. The exposure-response association between PM concentration and hospital visits for asthma exacerbations was approximately linear. In conclusion, this study found that short-term elevations in PM concentration may increase the risk of asthma exacerbations. Our findings contribute to the limited scientific literature concerning the acute effects of PM on asthma morbidity outcomes in developing countries.
中国关于细颗粒物(PM)的数据于2013年首次公布。本研究的主要目的是评估PM对中国北京哮喘发病率的急性影响。从北京市职工医疗费用报销数据中识别出2010年1月1日至2012年6月30日期间共978,658次哮喘就诊,其中包括928,607次门诊就诊、40,063次急诊就诊和9988次住院治疗。应用广义相加泊松模型探讨PM与医疗服务利用之间的关联。PM的日均浓度为99.5μg/m³,范围为7.2μg/m³至492.8μg/m³。环境PM浓度与哮喘相关医疗服务利用的增加显著相关。当日PM浓度每增加10μg/m³,总就诊次数、门诊就诊次数和急诊就诊次数分别显著增加0.67%(95%CI,0.53%-0.81%)、0.65%(95%CI,0.51%-0.80%)和0.49%(95%CI,0.35%-0.64%)。PM浓度与哮喘加重住院就诊之间的暴露-反应关联近似线性。总之,本研究发现PM浓度的短期升高可能会增加哮喘加重的风险。我们的研究结果为关于PM对发展中国家哮喘发病结局急性影响的有限科学文献做出了贡献。