Chen Wan-Zhi, Yu Shi-Tong, Xie Rong, Lv Yun-Xia, Xu De-Bin, Yu Ji-Chun
Department of Thyroid and Neck Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Department of Otolaryngology, Head and Neck Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Oncotarget. 2017 Jul 18;8(29):48240-48247. doi: 10.18632/oncotarget.18443.
This study evaluated the predictive value of the preoperative albumin/globulin ratio (AGR) in laryngeal squamous cell carcinoma (LSCC) retrospectively, which has not been reported before. The current study enrolled 241 newly diagnosed LSCC patients in the Second Affiliated Hospital of Nanchang University between January 2005 and December 2010. The optimal AGR cut-off value for overall survival (OS) was determined to be 1.28. Univariate survival analysis identified sex, low AGR, T classification, histological grade and nodal metastasis as factors associated with poor OS. Additionally, a low AGR, T classification, nodal metastasis, and histological grade were associated with poor disease-free survival (DFS) in LSCC patients. In multivariate survival analysis, nodal metastasis and a low AGR remained significant for OS and DFS. Our preliminary study revealed that low preoperative AGR could serve as a valuable and easily-assessed blood-based indicator to predict the prognosis of LSCC patients.
本研究回顾性评估了术前白蛋白/球蛋白比值（AGR）在喉鳞状细胞癌（LSCC）中的预测价值，此前尚无相关报道。本研究纳入了2005年1月至2010年12月期间在南昌大学第二附属医院新诊断的241例LSCC患者。确定总体生存（OS）的最佳AGR临界值为1.28。单因素生存分析确定性别、低AGR、T分类、组织学分级和淋巴结转移为与OS不良相关的因素。此外，低AGR、T分类、淋巴结转移和组织学分级与LSCC患者的无病生存（DFS）不良相关。在多因素生存分析中，淋巴结转移和低AGR对OS和DFS仍具有显著性。我们的初步研究表明，术前低AGR可作为预测LSCC患者预后的有价值且易于评估的血液指标。
