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主动脉瘤或夹层修复术后脊髓梗死的发生率。

Rates of Spinal Cord Infarction After Repair of Aortic Aneurysm or Dissection.

作者信息

Gialdini Gino, Parikh Neal S, Chatterjee Abhinaba, Lerario Michael P, Kamel Hooman, Schneider Darren B, Navi Babak B, Murthy Santosh B, Iadecola Costantino, Merkler Alexander E

机构信息

From the Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute (G.G., N.S.P., A.C., H.K., B.B.N., S.B.M., C.I., A.E.M.), Department of Neurology (N.S.P., M.P.L., H.K., B.B.N., S.B.M., C.I., A.E.M.), and Department of Vascular and Endovascular Surgery (D.B.S.), Weill Cornell Medicine, New York, NY; and Department of Neurology, New York-Presbyterian Queens, Flushing (M.P.L.).

出版信息

Stroke. 2017 Aug;48(8):2073-2077. doi: 10.1161/STROKEAHA.117.017071. Epub 2017 Jun 27.

Abstract

BACKGROUND AND PURPOSE

The rate of spinal cord infarction (SCI) after surgical or endovascular repair of an aortic aneurysm or dissection is unclear.

METHODS

Using administrative claims data, we identified adult patients discharged from nonfederal acute care hospitals in California, New York, and Florida who underwent surgical or endovascular repair of an aortic aneurysm or dissection between 2005 and 2013. Patients with SCI diagnosed before the aortic repair were excluded. Our primary outcome was an SCI during the index hospitalization for aortic repair. Descriptive statistics were used to estimate crude rates of SCI. Analyses were stratified by whether the aneurysm or dissection had ruptured and by type of repair (surgical versus endovascular).

RESULTS

We identified 91 212 patients who had repair of an aortic aneurysm or dissection. SCI occurred in 235 cases (0.26%; 95% confidence interval [CI], 0.22%-0.29%). In patients with ruptured aneurysm or dissection, the rate of SCI was 0.74% (95% CI, 0.60%-0.88%) compared with 0.16% (95% CI, 0.13%-0.19%) with unruptured aneurysm. In secondary analyses, rates of SCI were similar after endovascular repair (0.91%; 95% CI, 0.62%-1.19%) compared with surgical repair (0.68%; 95% CI, 0.53%-0.83%; =0.147) of ruptured aortic aneurysm or dissection; however, rates of SCI were higher after surgical repair (0.20%; 95% CI, 0.15%-0.25%) versus endovascular repair (0.11%; 95% CI, 0.08%-0.14%; <0.001) of unruptured aneurysm.

CONCLUSIONS

SCI occurs in ≈1 in 130 patients undergoing aortic dissection or ruptured aortic aneurysm repair and in 1 in 600 patients undergoing unruptured aortic aneurysm repair.

摘要

背景与目的

主动脉瘤或主动脉夹层手术或血管内修复术后脊髓梗死(SCI)的发生率尚不清楚。

方法

利用管理索赔数据,我们确定了2005年至2013年间在加利福尼亚州、纽约州和佛罗里达州非联邦急症医院出院的成年患者,这些患者接受了主动脉瘤或主动脉夹层的手术或血管内修复。排除在主动脉修复术前被诊断为SCI的患者。我们的主要结局是主动脉修复索引住院期间发生的SCI。采用描述性统计来估计SCI的粗发生率。分析按动脉瘤或夹层是否破裂以及修复类型(手术与血管内)进行分层。

结果

我们确定了91212例接受主动脉瘤或主动脉夹层修复的患者。235例发生了SCI(0.26%;95%置信区间[CI],0.22%-0.29%)。在动脉瘤或夹层破裂的患者中,SCI发生率为0.74%(95%CI,0.60%-0.88%),而未破裂动脉瘤患者为0.16%(95%CI,0.13%-0.19%)。在二次分析中,对于破裂的主动脉瘤或主动脉夹层,血管内修复后的SCI发生率(0.91%;95%CI,0.62%-1.19%)与手术修复(0.68%;95%CI,0.53%-0.83%;P=0.147)相似;然而,对于未破裂的动脉瘤,手术修复后的SCI发生率(0.20%;95%CI,0.15%-0.25%)高于血管内修复(0.11%;95%CI,0.08%-0.14%;P<0.001)。

结论

在接受主动脉夹层或破裂主动脉瘤修复的患者中,约130例中有1例发生SCI,在接受未破裂主动脉瘤修复的患者中,600例中有1例发生SCI。

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