Ishiguro Takashi, Kagiyama Naho, Uozumi Ryuji, Odashima Kyuto, Takaku Yotaro, Kurashima Kazuyoshi, Morita Satoshi, Takayanagi Noboru
Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Saitama, Japan.
Department of Biomedical Statistics and Bioinformatics, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Yale J Biol Med. 2017 Jun 23;90(2):165-181. eCollection 2017 Jun.
: Pneumonia is a major complication of influenza that contributes to mortality. Clinical characteristics and factors of influenza virus contributing to the severity and mortality of pneumonia have not been fully elucidated. : The objective was to clarify clinical characteristics and factors contributing to the severity and mortality of influenza-associated pneumonia (). : We retrospectively analyzed patients with . : From December 1999 to March 2016, 210 patients with a median age of 69 (range, 17 to 92) years with based on positive rapid antigen tests, increased antibody titers of paired sera, or positive results of reverse transcription polymerase chain reaction were admitted to our institution. A multivariate analysis found that advanced age (≥ 65 years), pneumonia subtypes (unclassified), diabetes mellitus, and acute kidney injury complicated with were independent factors associated with disease severity, whereas pneumonia subtypes (mixed viral and bacterial pneumonia and unclassified), healthcare-associated pneumonia, acute kidney injury complicated with , and severity on admission (severe) were independent factors associated with non-survival. : The clinical characteristics of are varied, and the contribution of several factors to the severity and mortality of suggest their importance in either preventing or managing after it develops.
肺炎是流感的主要并发症，可导致死亡。流感病毒导致肺炎严重程度和死亡的临床特征及因素尚未完全阐明。目的是明确流感相关性肺炎的临床特征及导致其严重程度和死亡的因素。我们对……患者进行了回顾性分析。1999年12月至2016年3月，210例患者因快速抗原检测阳性、双份血清抗体滴度升高或逆转录聚合酶链反应结果阳性而入住我院，这些患者的中位年龄为69岁（范围17至92岁）。多因素分析发现，高龄（≥65岁）、肺炎亚型（未分类）、糖尿病以及合并……的急性肾损伤是与疾病严重程度相关的独立因素，而肺炎亚型（混合病毒和细菌性肺炎及未分类）、医疗保健相关性肺炎、合并……的急性肾损伤以及入院时的严重程度（重度）是与死亡相关的独立因素。流感相关性肺炎的临床特征各不相同，多种因素对其严重程度和死亡的影响表明它们在预防流感相关性肺炎或在其发生后进行管理方面具有重要意义。
