Dorri Mahyar, Hashemitabar Shirin, Hosseinzadeh Hossein
a Department of Pharmacognosy, School of Pharmacy , Mashhad University of Medical Sciences , Mashhad , Iran.
b Biotechnology Research Center , Mashhad University of Medical Sciences , Mashhad , Iran.
Drug Chem Toxicol. 2018 Jul;41(3):338-351. doi: 10.1080/01480545.2017.1417995. Epub 2018 Jan 10.
Cinnamon (Cinnamomum zeylanicum, Lauraceae) is a food additive greatly used for its taste. However, recently this medicinal plant has been brought to attention due to its medical effects. Cinnamon has constituents such as cinnamaldehyde and cinnamic acid that offers some health benefits including antioxidant and free-radical scavenging properties, lowering of blood glucose, anti-cholesterolemic, analgesic, antimicrobial, anti-inflammatory, anti-yeast, anti-secretagogue, and anti-gastric ulcer effects. This review summarizes various in vitro and animal studies on the protective effects of cinnamon against natural and chemical toxins. These studies consider the antidotal and/or protective effects of cinnamon and its major constituents against natural toxins and chemical-induced toxicities. It has been mentioned that cinnamon and its main constituents can ameliorate the toxicity of chemical toxins in liver, kidney, blood, brain, embryo, reproductive system, heart, spleen in part through antioxidant effect, radical scavenging, reducing lipid peroxidation, anti-inflammatory, fungistatic and fungicidal activities, modulation of CK-MB, LDH, TNF-α, IL-6, mitogen-activated protein kinase (MAPK), and nuclear factor-ĸB (NF-ĸB) signaling pathways.
肉桂（樟科锡兰肉桂）是一种因其味道而被大量使用的食品添加剂。然而，最近这种药用植物因其医学功效而受到关注。肉桂含有肉桂醛和肉桂酸等成分，具有一些健康益处，包括抗氧化和清除自由基特性、降低血糖、抗胆固醇、止痛、抗菌、抗炎、抗酵母、抗促分泌素和抗胃溃疡作用。本综述总结了关于肉桂对天然毒素和化学毒素保护作用的各种体外和动物研究。这些研究探讨了肉桂及其主要成分对天然毒素和化学诱导毒性的解毒和/或保护作用。已经提到，肉桂及其主要成分可以部分通过抗氧化作用、清除自由基、减少脂质过氧化、抗炎、抑菌和杀菌活性、调节肌酸激酶同工酶（CK-MB）、乳酸脱氢酶（LDH）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、丝裂原活化蛋白激酶（MAPK）和核因子-κB（NF-κB）信号通路来减轻化学毒素对肝脏、肾脏、血液、大脑、胚胎、生殖系统、心脏、脾脏的毒性。
