• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

硫化氢可保护C57BL/6小鼠模型免受实验性脑型疟疾的侵害。

Hydrogen sulfide protects against the development of experimental cerebral malaria in a C57BL/6 mouse model.

作者信息

Jiang Ping, Xu Zhishen, Xiao Baiquan, Han Zhong, Huang Jiehong, Xu Jianbang, Lun Zhaorong, Zhou Wenliang

机构信息

School of Life Sciences, Sun Yat‑Sen University, Guangzhou, Guangdong 510275, P.R. China.

出版信息

Mol Med Rep. 2017 Aug;16(2):2045-2050. doi: 10.3892/mmr.2017.6854. Epub 2017 Jun 23.

DOI:10.3892/mmr.2017.6854
PMID:28656241
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5561995/
Abstract

Hydrogen sulfide (H2S) has anti‑inflammatory and neuroprotective properties, particularly during pathological processes. Experimental cerebral malaria (ECM), which is caused by vascular leakage into the brain, is characterized by inflammation, neurological deficits and cerebral hemorrhage. The present study investigated the correlation between ECM genesis and the levels of H2S. The results indicated that the levels of H2S derived from the brain decreased over time following ECM infection, and that the low H2S bioavailability was partially caused by decreased expression of the H2S generating enzyme, cystathionine‑β‑synthase. Administration of NaHS (an exogenous donor of H2S) provided protection against ECM. NaHS inhibited the destruction of the blood brain barrier and the secretion of proinflammatory biomarkers, including interluekin‑18, matrix metalloproteinase‑9 and serum cluster of differentiation 40 into the brain during ECM. In conclusion, these results suggested that low levels of H2S in brain contributed to the progression of ECM, and that H2S donor administration may represent a potential protective therapy against ECM.

摘要

硫化氢（H₂S）具有抗炎和神经保护特性，尤其是在病理过程中。实验性脑型疟疾（ECM）由血管渗漏入脑引起，其特征为炎症、神经功能缺损和脑出血。本研究调查了ECM发生与H₂S水平之间的相关性。结果表明，ECM感染后，脑源性H₂S水平随时间下降，且低H₂S生物利用度部分是由H₂S生成酶胱硫醚-β-合酶表达降低所致。给予NaHS（一种外源性H₂S供体）可预防ECM。NaHS可抑制ECM期间血脑屏障的破坏以及促炎生物标志物（包括白细胞介素-18、基质金属蛋白酶-9和血清分化簇40）向脑内的分泌。总之，这些结果表明脑内低水平H₂S促成了ECM的进展，给予H₂S供体可能是一种针对ECM的潜在保护性治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4083/5561995/338627bc9397/MMR-16-02-2045-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4083/5561995/eb625f349ce3/MMR-16-02-2045-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4083/5561995/79b80218f485/MMR-16-02-2045-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4083/5561995/02320930149e/MMR-16-02-2045-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4083/5561995/2a814efdb8c8/MMR-16-02-2045-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4083/5561995/338627bc9397/MMR-16-02-2045-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4083/5561995/eb625f349ce3/MMR-16-02-2045-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4083/5561995/79b80218f485/MMR-16-02-2045-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4083/5561995/02320930149e/MMR-16-02-2045-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4083/5561995/2a814efdb8c8/MMR-16-02-2045-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4083/5561995/338627bc9397/MMR-16-02-2045-g04.jpg

相似文献

1
Hydrogen sulfide protects against the development of experimental cerebral malaria in a C57BL/6 mouse model.硫化氢可保护C57BL/6小鼠模型免受实验性脑型疟疾的侵害。
Mol Med Rep. 2017 Aug;16(2):2045-2050. doi: 10.3892/mmr.2017.6854. Epub 2017 Jun 23.
2
Hydrogen Sulfide Ameliorates Homocysteine-Induced Alzheimer's Disease-Like Pathology, Blood-Brain Barrier Disruption, and Synaptic Disorder.硫化氢可改善同型半胱氨酸诱导的阿尔茨海默病样病理、血脑屏障破坏和突触紊乱。
Mol Neurobiol. 2016 May;53(4):2451-2467. doi: 10.1007/s12035-015-9212-4. Epub 2015 May 28.
3
Hydrogen Sulfide Ameliorates Early Brain Injury Following Subarachnoid Hemorrhage in Rats.硫化氢改善大鼠蛛网膜下腔出血后的早期脑损伤。
Mol Neurobiol. 2016 Aug;53(6):3646-3657. doi: 10.1007/s12035-015-9304-1. Epub 2015 Jun 26.
4
Preconditioning with hydrogen sulfide ameliorates cerebral ischemia/reperfusion injury in a mouse model of transient middle cerebral artery occlusion.硫化氢预处理减轻小鼠短暂性大脑中动脉闭塞模型的脑缺血/再灌注损伤。
Chem Biol Interact. 2019 Sep 1;310:108738. doi: 10.1016/j.cbi.2019.108738. Epub 2019 Jul 5.
5
Hydrogen Sulfide Attenuates Tissue Plasminogen Activator-Induced Cerebral Hemorrhage Following Experimental Stroke.硫化氢减轻实验性中风后组织型纤溶酶原激活剂诱导的脑出血。
Transl Stroke Res. 2016 Jun;7(3):209-19. doi: 10.1007/s12975-016-0459-5. Epub 2016 Mar 28.
6
Hydrogen sulfide slows down progression of experimental Alzheimer's disease by targeting multiple pathophysiological mechanisms.硫化氢通过靶向多种病理生理机制减缓实验性阿尔茨海默病的进展。
Neurobiol Learn Mem. 2013 Sep;104:82-91. doi: 10.1016/j.nlm.2013.05.006. Epub 2013 May 31.
7
MMP-9- and NMDA receptor-mediated mechanism of diabetic renovascular remodeling and kidney dysfunction: hydrogen sulfide is a key modulator.基质金属蛋白酶-9和N-甲基-D-天冬氨酸受体介导的糖尿病性肾血管重塑及肾功能障碍机制：硫化氢是关键调节因子。
Nitric Oxide. 2015 Apr 30;46:172-85. doi: 10.1016/j.niox.2015.02.003. Epub 2015 Feb 7.
8
Hydrogen sulfide protects blood-brain barrier integrity following cerebral ischemia.硫化氢保护脑缺血后血脑屏障的完整性。
J Neurochem. 2014 Jun;129(5):827-38. doi: 10.1111/jnc.12695. Epub 2014 Mar 27.
9
Protective Effects of Hydrogen Sulfide in the Ageing Kidney.硫化氢对衰老肾脏的保护作用。
Oxid Med Cell Longev. 2016;2016:7570489. doi: 10.1155/2016/7570489. Epub 2016 Nov 1.
10
Protective effects of hydrogen sulfide in a rat model of traumatic brain injury via activation of mitochondrial adenosine triphosphate-sensitive potassium channels and reduction of oxidative stress.硫化氢通过激活线粒体三磷酸腺苷敏感性钾通道和减少氧化应激对创伤性脑损伤大鼠模型的保护作用。
J Surg Res. 2013 Oct;184(2):e27-35. doi: 10.1016/j.jss.2013.03.067. Epub 2013 Apr 8.

引用本文的文献

1
Impact of Reactive Sulfur Species on : Modulating Viability, Motility, and Biofilm Degradation Capacity.活性硫物种对调节活力、运动能力和生物膜降解能力的影响。
Antioxidants (Basel). 2024 Feb 19;13(2):245. doi: 10.3390/antiox13020245.
2
Therapeutic Potential of Carbon Monoxide (CO) and Hydrogen Sulfide (HS) in Hemolytic and Hemorrhagic Vascular Disorders-Interaction between the Heme Oxygenase and HS-Producing Systems.一氧化碳（CO）和硫化氢（HS）在溶血性和出血性血管疾病中的治疗潜力——血红素加氧酶和 HS 产生系统之间的相互作用。
Int J Mol Sci. 2020 Dec 23;22(1):47. doi: 10.3390/ijms22010047.
3
The H₂S Donor GYY4137 Stimulates Reactive Oxygen Species Generation in BV2 Cells While Suppressing the Secretion of TNF and Nitric Oxide.

本文引用的文献

1
Loss of Toll-like receptor 7 alters cytokine production and protects against experimental cerebral malaria.Toll样受体7缺失改变细胞因子产生并预防实验性脑型疟疾。
Malar J. 2014 Sep 5;13:354. doi: 10.1186/1475-2875-13-354.
2
ApoE-deficient promotes blood-brain barrier disruption in experimental autoimmune encephalomyelitis via alteration of MMP-9.载脂蛋白E缺乏通过基质金属蛋白酶-9的改变促进实验性自身免疫性脑脊髓炎中的血脑屏障破坏。
J Mol Neurosci. 2014;54(2):282-90. doi: 10.1007/s12031-014-0291-x. Epub 2014 May 1.
3
Anti-inflammatory and cytoprotective actions of hydrogen sulfide: translation to therapeutics.
H₂S 供体 GYY4137 刺激 BV2 细胞产生活性氧，同时抑制 TNF 和一氧化氮的分泌。
Molecules. 2018 Nov 14;23(11):2966. doi: 10.3390/molecules23112966.
硫化氢的抗炎和细胞保护作用：向治疗领域的转化
Antioxid Redox Signal. 2015 Feb 10;22(5):398-410. doi: 10.1089/ars.2014.5901. Epub 2014 Apr 15.
4
Plasmodium berghei ANKA (PbA) infection of C57BL/6J mice: a model of severe malaria.伯氏疟原虫ANKA株（PbA）感染C57BL/6J小鼠：一种重症疟疾模型。
Methods Mol Biol. 2013;1031:203-13. doi: 10.1007/978-1-62703-481-4_23.
5
Investigation of hydrogen sulfide gas as a treatment against P. falciparum, murine cerebral malaria, and the importance of thiolation state in the development of cerebral malaria.研究硫化氢气体作为治疗恶性疟原虫、鼠脑型疟疾的方法，以及巯基化状态在脑型疟疾发展中的重要性。
PLoS One. 2013;8(3):e59271. doi: 10.1371/journal.pone.0059271. Epub 2013 Mar 26.
6
Malaria biology and disease pathogenesis: insights for new treatments.疟疾生物学和发病机制：新疗法的启示。
Nat Med. 2013 Feb;19(2):156-67. doi: 10.1038/nm.3073. Epub 2013 Feb 6.
7
Molecular basis of erythrocyte adhesion to endothelial cells in diseases.疾病中红细胞与内皮细胞黏附的分子基础。
Clin Hemorheol Microcirc. 2013;53(1-2):11-21. doi: 10.3233/CH-2012-1572.
8
Antigen presentation by endothelial cells: what role in the pathophysiology of malaria?内皮细胞的抗原呈递：在疟疾病理生理学中起什么作用？
Trends Parasitol. 2012 Apr;28(4):151-60. doi: 10.1016/j.pt.2012.01.004. Epub 2012 Feb 25.
9
Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS/NF-κB/COX-2 pathway.硫化氢通过抑制 ROS/NF-κB/COX-2 通路保护 HaCaT 细胞免受化学缺氧诱导的细胞毒性和炎症。
PLoS One. 2011;6(7):e21971. doi: 10.1371/journal.pone.0021971. Epub 2011 Jul 14.
10
A rapid murine coma and behavior scale for quantitative assessment of murine cerebral malaria.一种快速的小鼠昏迷和行为量表，用于定量评估小鼠脑型疟疾。
PLoS One. 2010 Oct 1;5(10):e13124. doi: 10.1371/journal.pone.0013124.