Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai, 200032, China.
Angew Chem Int Ed Engl. 2017 Aug 7;56(33):9971-9975. doi: 10.1002/anie.201705734. Epub 2017 Jul 18.
A new method for the on-site preparation of tetrafluoroethylene (TFE) and a procedure for its efficient use in pentafluoroethylation by fluoride addition were developed by using a simple two-chamber system. The on-site preparation of TFE was accomplished by dimerization of difluorocarbene derived from (trifluoromethyl)trimethylsilane (TMSCF ) under mild conditions. Other fluoroalkylation reactions, such as (aryloxy)tetrafluoroethylation and tetrafluoroethylation processes, were also achieved using a similar approach. This work not only demonstrates a convenient and safe approach for the generation and use of TFE in academic laboratories, but also provides a new strategy for pentafluoroethylation.
开发了一种使用简单的双室系统现场制备四氟乙烯（TFE）和有效进行氟加成五氟乙基化的方法。通过（三氟甲基）三甲基硅烷（TMSCF ）衍生的二氟卡宾的二聚化在温和条件下完成 TFE 的现场制备。还使用类似的方法实现了其他氟烷基化反应，例如（芳氧基）四氟乙基化和四氟乙基化过程。这项工作不仅展示了在学术实验室中生成和使用 TFE 的便捷和安全方法，而且还为五氟乙基化提供了新策略。
