Sala Cecilia, Medana Claudio, Pellegrino Raffaele, Aigotti Riccardo, Bello Federica Dal, Bianchi Giancarlo, Davoli Enrico
1 Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
2 Mass Spectrometry Laboratory, Department of Environmental Health Sciences, IRCCS Istituto di Ricerche Farmacologiche "Mario Negri", Milano, Italy.
Eur J Mass Spectrom (Chichester). 2017 Apr;23(2):64-69. doi: 10.1177/1469066717699078. Epub 2017 Mar 24.
Recently, the formation of carbonyl compound within e-cigarettes usage has been reported. The aim of this study was to develop a new analytical method for the direct analysis of carbonyl compounds in vaporized liquids. Two different types of e-cigarettes and different puff's duration have been evaluated, using a modified smoking machine for vapor generation. An isotopic dilution approach, based on deuterated internal standard addition to the e-liquid before filling the e-cigarette tank, has been developed. Carbonyl compounds have been sampled in vapors using a direct, simple, solid-phase microextraction technique with on-fiber derivatization. Related oximes have been analyzed by gas chromatography/mass spectrometry technique. Results confirmed that new carbonyl compounds are formed during the vaping process, and that formation depends both from the heating device and from puffing topography.
最近，有报道称使用电子烟时会形成羰基化合物。本研究的目的是开发一种新的分析方法，用于直接分析汽化液体中的羰基化合物。使用改良的吸烟机产生蒸汽，对两种不同类型的电子烟和不同的抽吸持续时间进行了评估。已开发出一种同位素稀释方法，即在填充电子烟烟弹之前向电子烟液中添加氘代内标。使用直接、简单的带有纤维上衍生化的固相微萃取技术对蒸汽中的羰基化合物进行采样。相关的肟通过气相色谱/质谱技术进行分析。结果证实，在电子烟抽吸过程中会形成新的羰基化合物，其形成既取决于加热装置，也取决于抽吸情况。
