Norouzy Abdolreza, Hasanzade Daloee Mahdi, Khoshnasab Amir Hosein, Khoshnasab Adeleh, Farrokhi Javad, Nematy Mohsen, Safarian Mohammad, Nezafati Pouya, Alinezhad-Namaghi Maryam
aNutrition Department, Faculty of Medicine bCardiovascular Research Center, Qaem Hospital, School of Medicine cCardiac Surgery Research Committee, Mashhad University of Medical Sciences, Mashhad dBaqiyatallah University of Medical Sciences eUniversity of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Blood Press Monit. 2017 Oct;22(5):253-257. doi: 10.1097/MBP.0000000000000272.
It is believed that Ramadan fasting regulates blood pressure, heart rate, and other cardiovascular risk factors. This study aimed to investigate the effect of Ramadan fasting on ambulatory blood pressure in hypertensive patients.
This prospective, observational study was carried out in two groups: one group included hypertensive patients treated with two antihypertensive agents (n=6) and the other group included healthy individuals (n=12). We performed 24-h blood pressure monitoring at four time points: before Ramadan, during the first and last 10 days of Ramadan, and 1 month after Ramadan. All hypertensive patients followed their twice-daily treatment regimen. Mean 24-h blood pressure (as well as mean blood pressure values during awake and sleep periods), body weight, and waist circumference were measured in the two groups.
There were no significant differences in the trends of systolic and diastolic blood pressure between the hypertensive and nonhypertensive groups during Ramadan and 1 month after it. However, the trends of variations in heart rate and body weight were not significantly different in the two groups (P<0.001 and P=0.016, respectively). There was a significant increase in heart rate during the first period of Ramadan in hypertensive patients (P=0.018), whereas it improved during the post-Ramadan period in comparison with the second period of measurements (P=0.019). Furthermore, there was a significant decline in heart rate during the post-Ramadan measurement compared with that before Ramadan in the nonhypertensive group (P=0.008).In addition, there was a significant weight gain in the third period in comparison with the previous period in the hypertensive group (73.1±11 vs. 72.2±12; P=0.011).
This finding indicates that Ramadan fasting might be nonthreatening for patients with essential hypertension if the treatment regimen is complied with.
据信斋月禁食可调节血压、心率及其他心血管危险因素。本研究旨在调查斋月禁食对高血压患者动态血压的影响。
这项前瞻性观察性研究分为两组进行：一组包括接受两种抗高血压药物治疗的高血压患者（n = 6），另一组包括健康个体（n = 12）。我们在四个时间点进行了24小时血压监测：斋月前、斋月的第一个10天和最后10天期间以及斋月后1个月。所有高血压患者均遵循每日两次的治疗方案。测量了两组的平均24小时血压（以及清醒和睡眠期间的平均血压值）、体重和腰围。
在斋月期间及其后1个月，高血压组和非高血压组的收缩压和舒张压趋势无显著差异。然而，两组心率和体重的变化趋势无显著差异（分别为P<0.001和P = 0.016）。高血压患者在斋月的第一个阶段心率显著增加（P = 0.018），而与第二次测量阶段相比，斋月后阶段心率有所改善（P = 0.019）。此外，与斋月前相比，非高血压组在斋月后测量时心率显著下降（P = 0.008）。此外，高血压组在第三个阶段的体重与前一阶段相比显著增加（73.1±11对72.2±12；P = 0.011）。
这一发现表明，如果遵守治疗方案，斋月禁食对原发性高血压患者可能没有威胁。
