Hammoud Sabah, Saad Iman, Karam Rita, Abou Jaoude Fayez, van den Bemt Bart J F, Kurdi Mazen
Laboratory of Experimental and Clinical Pharmacology, Faculty of Sciences, Section 1, Lebanese University, Rafic Hariri Educational Campus, Hadat, Lebanon.
Department of Pharmacy, Radboud University Medical Center, Nijmegen, Netherlands.
J Nutr Metab. 2021 Mar 29;2021:6610455. doi: 10.1155/2021/6610455. eCollection 2021.
Conflicting results are reported on the effect of Ramadan fasting on the cardiovascular health of patients with hypertension, a highly prevalent cardiovascular disease risk factor. This research aimed to evaluate the impact of fasting on cardiac health and heart rate variability (as a measure of cardiac stress) of hypertensive patients.
Patients with controlled hypertension were followed in a prospective cohort during and after Ramadan. Lipid panel and blood glucose were measured at the end of each phase. Blood pressure and heart rate variability were monitored in the morning, afternoon, and evening of each follow-up day.
The study included 58 subjects (mean age: 54 ± 11.5 years, 52% male). Fasting did not affect body composition, lipid panel parameters, and blood pressure of hypertensive subjects; males only presented lower body weight and hip circumference during Ramadan. Blood glucose was significantly higher during Ramadan. Fasting significantly increased HRV during the afternoon period.
Ramadan intermittent fasting reduces cardiac stress among hypertensive patients controlled by and adherent to hypertensive medication, without affecting their hypertensive state.
关于斋月禁食对高血压患者心血管健康的影响，研究结果相互矛盾，而高血压是一种非常普遍的心血管疾病风险因素。本研究旨在评估禁食对高血压患者心脏健康和心率变异性（作为心脏应激的一种衡量指标）的影响。
在斋月期间及之后，对血压得到控制的高血压患者进行前瞻性队列研究。在每个阶段结束时测量血脂和血糖。在每个随访日的早晨、下午和晚上监测血压和心率变异性。
该研究纳入了58名受试者（平均年龄：54±11.5岁，52%为男性）。禁食并未影响高血压受试者的身体成分、血脂参数和血压；仅男性在斋月期间体重和臀围较低。斋月期间血糖显著升高。禁食显著增加了下午时段的心率变异性。
斋月间歇性禁食可降低接受高血压药物治疗并坚持服药的高血压患者的心脏应激，而不影响其高血压状态。
