Department of Nutrition, Biochemistry and Nutrition Research Center, University of Medical Sciences, Mashad 91779-48564, Iran.
Nutr J. 2012 Sep 10;11:69. doi: 10.1186/1475-2891-11-69.
Previous research has shown that Ramadan fasting has beneficial effects on cardiovascular risk factors, however there are controversies. In the present study, the effect of Ramadan fasting on cardiovascular risk factors has been investigated.
This is a prospective observational study that was carried out in a group of patients with at least one cardiovascular risk factor (including history of documented previous history of either coronary artery disease (CAD), metabolic syndrome or cerebro-vascular disease in past 10 y). Eighty two volunteers including 38 male and 44 female, aged 29-70 y, mean 54.0 ± 10 y, with a previous history of either coronary artery disease, metabolic syndrome or cerebro-vascular disease were recruited. Subjects attended the metabolic unit after at least 10 h fasting, before and after Ramadan who were been fasting for at least 10 days. A fasting blood sample was obtained, blood pressure was measured and body mass index (BMI) was calculated. Lipids profile, fasting blood sugar (FBS) and insulin, homocysteine (hcy), high-sensitivity C-reactive protein (hs-CRP) and complete blood count (CBC) were analyzed on all blood samples.
A significant improvement in 10 years coronary heart disease risk (based on Framingham risk score) was found (13.0 ± 8 before Ramadan and 10.8 ±7 after Ramadan, P <0.001, t test).There was a significant higher HDL-c, WBC, RBC and platelet count (PLT), and lower plasma cholesterol, triglycerides, LDL-c, VLDL-c, systolic blood pressure, body mass index and waist circumference after Ramadan (P <0.05, t test). The changes in FBS, insulin, Homeostasis Model Assessment Insulin Resistance (HOMA-IR), hcy, hs-CRP and diastolic blood pressure before and after Ramadan were not significant (P >0.05, t test).
This study shows a significant improvement in 10 years coronary heart disease risk score and other cardiovascular risk factors such as lipids profile, systolic blood pressure, weight, BMI and waist circumference in subjects with a previous history of cardiovascular disease.
先前的研究表明，斋月禁食对心血管危险因素有有益影响，但存在争议。本研究旨在探讨斋月禁食对心血管危险因素的影响。
这是一项前瞻性观察研究，在一组至少存在一个心血管危险因素（包括过去 10 年内有冠心病、代谢综合征或脑血管疾病病史）的患者中进行。招募了 82 名志愿者，包括 38 名男性和 44 名女性，年龄 29-70 岁，平均 54.0±10 岁，既往有冠心病、代谢综合征或脑血管疾病病史。受试者在至少禁食 10 小时后，在斋月前和斋月后至少禁食 10 天，前往代谢单元就诊。采集空腹血样，测量血压，计算体重指数（BMI）。分析所有血样的血脂谱、空腹血糖（FBS）和胰岛素、同型半胱氨酸（hcy）、高敏 C 反应蛋白（hs-CRP）和全血细胞计数（CBC）。
发现 10 年冠心病风险（基于弗雷明汉风险评分）显著改善（斋月前 13.0±8，斋月后 10.8±7，P<0.001，t 检验）。斋月后，HDL-c、WBC、RBC 和血小板计数（PLT）显著升高，血浆胆固醇、甘油三酯、LDL-c、VLDL-c、收缩压、BMI 和腰围显著降低（P<0.05，t 检验）。斋月前后 FBS、胰岛素、稳态模型评估胰岛素抵抗（HOMA-IR）、hcy、hs-CRP 和舒张压的变化无统计学意义（P>0.05，t 检验）。
本研究表明，既往有心血管疾病病史的患者，斋月禁食可显著改善 10 年冠心病风险评分和其他心血管危险因素，如血脂谱、收缩压、体重、BMI 和腰围。
