Philip Nigi Ross, Srinivas Teerthanath, Naagar Ruhisalma, Srinivas Venkatesh
Junior Resident, Department of Pathology, K.S.Hegde Medical Academy, Mangalore, Karnataka, India.
Professor, Department of Pathology, K.S.Hegde Medical Academy, Mangalore, Karnataka, India.
J Clin Diagn Res. 2017 May;11(5):ED24-ED25. doi: 10.7860/JCDR/2017/22341.9885. Epub 2017 May 1.
Small Cell Carcinoma (SCC) of the salivary gland is a rare and aggressive tumour accounting for about less than 1% of the salivary gland tumours. Submandibular gland involvement is extremely rare. These tumours frequently present with metastasis to lymph node and distant organs. We report a case of a 30-year-old male patient who presented with a swelling on the left side of the face below the jaw and the floor of the mouth. The tumour was excised followed by histopathological evaluation and diagnosed as SCC of left submandibular gland. Immunohistochemistry was positive for pan cytokeratin, synaptophysin, chromogranin, Ki-67, CK5/6, and negative for Thyroid Transcription Factor (TTF-1) which confirmed that the tumour was SCC of submandibular salivary gland.
涎腺小细胞癌(SCC)是一种罕见的侵袭性肿瘤,约占涎腺肿瘤的1%以下。下颌下腺受累极为罕见。这些肿瘤常伴有淋巴结和远处器官转移。我们报告一例30岁男性患者,其下颌下方及口底左侧面部出现肿胀。肿瘤切除后进行组织病理学评估,诊断为左下颌下腺SCC。免疫组化显示全细胞角蛋白、突触素、嗜铬粒蛋白、Ki-67、CK5/6呈阳性,甲状腺转录因子(TTF-1)呈阴性,证实该肿瘤为下颌下涎腺SCC。