Yordanov Daniel, Boyanova Lyudmila, Markovska Rumyana, Ilieva Juliana, Andreev Nikolay, Gergova Galina, Mitov Ivan
Department of Medical Microbiology, Medical University of Sofia, Sofia, Bulgaria.
Department of Social Medicine and Healthcare Management, Medical University of Sofia, Sofia, Bulgaria.
Gastroenterol Res Pract. 2017;2017:9212143. doi: 10.1155/2017/9212143. Epub 2017 Jun 4.
The aim of this study was to assess the association between some dietary factors and prevalence of infection or strain virulence in 294 adult asymptomatic blood donors. . Seroprevalence was evaluated using ELISA. Logistic regression was used. . Anti- IgG prevalence was 72.4%, and CagA IgG seroprevalence was 49.3%. In the multivariate analyses, the frequent (>5 days per week) honey consumption was associated with both reduced seroprevalence OR, 0.68 with 95% confidence interval (CI), 0.473-0.967 and reduced CagA IgG seroprevalence OR, 0.65 with 95% CI, 0.486-0859. Frequent (>5 days per week) yoghurt consumption also was associated with lower virulence of the strains (CagA IgG OR, 0.56 with 95% CI, 0.341-0.921). Smoking and consumption of the other dietary factors resulted in no significant differences in the prevalence of IgG and CagA IgG within the subject groups. . To the best of our knowledge, this is the first report revealing reverse associations between honey or yoghurt consumption and CagA IgG prevalence as well as between frequent honey consumption and lower prevalence of the infection. Regular honey and yoghurt consumption can be of value as a supplement in the control of therapy.
本研究旨在评估294名成年无症状献血者的某些饮食因素与感染患病率或菌株毒力之间的关联。采用酶联免疫吸附测定（ELISA）评估血清阳性率，并使用逻辑回归分析。抗IgG阳性率为72.4%，CagA IgG血清阳性率为49.3%。在多变量分析中，经常食用蜂蜜（每周>5天）与血清阳性率降低相关（比值比[OR]为0.68，95%置信区间[CI]为0.473 - 0.967），且与CagA IgG血清阳性率降低相关（OR为0.65，95% CI为0.486 - 0.859）。经常食用酸奶（每周>5天）也与菌株的较低毒力相关（CagA IgG OR为0.56，95% CI为0.341 - 0.921）。吸烟和其他饮食因素的摄入在各受试者组中，IgG和CagA IgG的患病率无显著差异。据我们所知，这是首次报告揭示蜂蜜或酸奶消费与CagA IgG患病率之间以及经常食用蜂蜜与感染较低患病率之间的反向关联。经常食用蜂蜜和酸奶作为辅助手段在控制治疗中可能具有价值。
