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关于治疗克罗恩病的系统药理学方法

Systems Pharmacological Approach of on Treating Crohn's Disease.

作者信息

Suh Su Yeon, An Won G

机构信息

Department of Pharmacology, School of Korean Medicine, Pusan National University, Yangsan, Gyeongnam 50612, Republic of Korea.

出版信息

Evid Based Complement Alternat Med. 2017;2017:4198035. doi: 10.1155/2017/4198035. Epub 2017 Jun 1.

DOI:10.1155/2017/4198035
PMID:28659988
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5474285/
Abstract

In East Asian traditional medicine, (PR) is widely used to treat amoebic dysentery and renowned for its anti-inflammatory effects. This study aimed to confirm evidence regarding the potential therapeutic effect of PR on Crohn's disease using a system network level based in silico approach. Study results showed that the compounds in PR are highly connected to Crohn's disease related pathways, biological processes, and organs, and these findings were confirmed by compound-target network, target-pathway network, and gene ontology analysis. Most compounds in PR have been reported to possess anti-inflammatory, anticancer, and antioxidant effects, and we found that these compounds interact with multiple targets in a synergetic way. Furthermore, the mRNA expressions of genes targeted by PR are elevated significantly in immunity-related organ tissues, small intestine, and colon. Our results suggest that the anti-inflammatory and repair and immune system enhancing effects of PR might have therapeutic impact on Crohn's disease.

摘要

在东亚传统医学中，白头翁（PR）被广泛用于治疗阿米巴痢疾，并以其抗炎作用而闻名。本研究旨在使用基于计算机模拟的系统网络水平方法，确认白头翁对克罗恩病潜在治疗效果的证据。研究结果表明，白头翁中的化合物与克罗恩病相关途径、生物学过程和器官高度相关，这些发现通过化合物-靶点网络、靶点-途径网络和基因本体分析得到了证实。据报道，白头翁中的大多数化合物具有抗炎、抗癌和抗氧化作用，并且我们发现这些化合物以协同方式与多个靶点相互作用。此外，白头翁靶向基因的mRNA表达在免疫相关器官组织、小肠和结肠中显著升高。我们的结果表明，白头翁的抗炎以及增强修复和免疫系统的作用可能对克罗恩病具有治疗作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c68/5474285/d1c4f7cae147/ECAM2017-4198035.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c68/5474285/cf7ff2cf3737/ECAM2017-4198035.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c68/5474285/2b51302575fc/ECAM2017-4198035.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c68/5474285/a25d9919a220/ECAM2017-4198035.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c68/5474285/a5beb48206a1/ECAM2017-4198035.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c68/5474285/d1c4f7cae147/ECAM2017-4198035.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c68/5474285/cf7ff2cf3737/ECAM2017-4198035.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c68/5474285/2b51302575fc/ECAM2017-4198035.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c68/5474285/a25d9919a220/ECAM2017-4198035.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c68/5474285/a5beb48206a1/ECAM2017-4198035.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c68/5474285/d1c4f7cae147/ECAM2017-4198035.005.jpg

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