Song Hemei, Sun Zengxian
Department of Pharmacy, The First People's Hospital of Lianyungang, 182 North Tongguan Road, Lianyungang, 222002, China.
3 Biotech. 2017 Jul;7(3):159. doi: 10.1007/s13205-017-0843-1. Epub 2017 Jun 29.
Both hyperglycaemia and hyperlipidaemia are major risk factors for the development of coronary artery diseases and atherosclerosis, and therefore therapeutic drugs must be developed for treatment of them. Pumpkin polysaccharides (PPs) are biomacromolecules with varying bioactivities. In this study, PPs were extracted with commercial thermostable α-amylase, and their hypolipidaemic and hypoglycaemic activities were evaluated. Twenty four KKAy mice were divided into two groups: control was fed with high-fat diet; while the PP group was fed with high-fat diet with the addition of PPs at the same time, for 6 weeks. PP diet reduced body weight gain, the levels of plasma insulin, serum triglyceride, cholesterol, low-density lipoprotein cholesterol and blasting blood glucose in mice and improved the level of high-density lipoprotein cholesterol and liver glycogen. Results indicate that PPs had high hypolipidaemic and hypoglycaemic activities and could be used as potential drugs for treatment of hyperlipidaemia and hyperglycaemia.
高血糖和高血脂都是冠状动脉疾病和动脉粥样硬化发展的主要危险因素，因此必须研发治疗药物来治疗它们。南瓜多糖（PPs）是具有多种生物活性的生物大分子。在本研究中，用商业热稳定α-淀粉酶提取PPs，并评估其降血脂和降血糖活性。将24只KKAy小鼠分为两组：对照组喂食高脂饮食；PP组同时喂食添加了PPs的高脂饮食，持续6周。PP饮食降低了小鼠的体重增加、血浆胰岛素水平、血清甘油三酯、胆固醇、低密度脂蛋白胆固醇水平和空腹血糖，并提高了高密度脂蛋白胆固醇水平和肝糖原水平。结果表明，PPs具有较高的降血脂和降血糖活性，可作为治疗高血脂和高血糖的潜在药物。
