Van 't Hoff Institute for Molecular Sciences, Faculty of Science, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, Netherlands.
Faculty of Humanities, Conservation and Restoration of Cultural Heritage, University of Amsterdam, Johannes Vermeerplein 1, 1071 DV, Amsterdam, Netherlands.
J Am Soc Mass Spectrom. 2017 Oct;28(10):2108-2116. doi: 10.1007/s13361-017-1716-x. Epub 2017 Jun 28.
Surface acoustic wave nebulisation (SAWN) mass spectrometry (MS) is a method to generate gaseous ions compatible with direct MS of minute samples at femtomole sensitivity. To perform SAWN, acoustic waves are propagated through a LiNbO sampling chip, and are conducted to the liquid sample, which ultimately leads to the generation of a fine mist containing droplets of nanometre to micrometre diameter. Through fission and evaporation, the droplets undergo a phase change from liquid to gaseous analyte ions in a non-destructive manner. We have developed SAWN technology for the characterisation of organic colourants in textiles. It generates electrospray-ionisation-like ions in a non-destructive manner during ionisation, as can be observed by the unmodified chemical structure. The sample size is decreased by tenfold to 1000-fold when compared with currently used liquid chromatography-MS methods, with equal or better sensitivity. This work underscores SAWN-MS as an ideal tool for molecular analysis of art objects as it is non-destructive, is rapid, involves minimally invasive sampling and is more sensitive than current MS-based methods. Graphical Abstract ᅟ.
表面声波雾化（SAWN）质谱（MS）是一种生成与直接 MS 兼容的气态离子的方法，可对纳摩尔级别的微量样品进行 femtomole 灵敏度检测。为了进行 SAWN，声波通过 LiNbO 采样芯片传播，并传导到液体样品，最终导致产生包含纳米到微米直径液滴的细雾。通过裂变和蒸发，液滴以非破坏性的方式经历从液体到气态分析物离子的相变。我们已经开发了 SAWN 技术，用于纺织品中有机着色剂的特征分析。在电离过程中，它以非破坏性的方式产生类似于电喷雾电离的离子，这可以通过未修饰的化学结构观察到。与目前使用的液相色谱-MS 方法相比，样品量减少了 10 到 1000 倍，而灵敏度相等或更高。这项工作强调了 SAWN-MS 作为艺术品分子分析的理想工具，因为它是非破坏性的、快速的、涉及微创采样，并且比当前基于 MS 的方法更灵敏。ᅟ.
