Li Jia-Ying, Li Ying, Jiang Zheng, Wang Rui-Tao, Wang Xi-Shan
Colorectal Cancer Surgery Department, The Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China E-mail :
Asian Pac J Cancer Prev. 2014;15(23):10501-4. doi: 10.7314/apjcp.2014.15.23.10501.
Colon cancer is the second most common cancer in developed countries. Activated platelets play a key role in inflammation and atherothrombosis, with mean platelet volume (MPV) is an early marker of platelet activation. The aim of the study was to clarify the relevance of MPV in patients with colon cancer.
We measured MPV levels in 128 patients with colon cancer before and after surgery, and 128 controls matched for age, gender, body mass index (BMI) and smoking status. The odds ratios (ORs) and 95% confidence intervals (CIs) for colon cancer were calculated using multivariate logistic regression analyses across MPV quartiles.
Patients with colon cancer had higher MPV compared with controls. Surgical tumor resection resulted in a significant decrease in MPV levels (11.4 fL vs 10.7 fL; p<0.001). A positive correlation between MPV and tumor-nodule-metastases (TNM) stage was found. Furthermore, after adjusting for other risk factors, the ORs (95%CIs) for colon cancer according to MPV quartiles were 1.000, 2.238 (1.014-4.943), 3.410 (1.528-7.613), and 5.379 (2.372-12.198), respectively.
The findings show that patients with colon cancer have higher MPV levels compared with controls, and these are reduced after surgery. In addition, MPV was found to be independently associated with the presence of colon cancer. Further studies are warranted to assess the utility of MPV as a novel diagnostic screening tool for colon cancer.
在发达国家，结肠癌是第二大常见癌症。活化血小板在炎症和动脉粥样硬化血栓形成中起关键作用，平均血小板体积（MPV）是血小板活化的早期标志物。本研究旨在阐明MPV在结肠癌患者中的相关性。
我们测量了128例结肠癌患者手术前后的MPV水平，并与128名年龄、性别、体重指数（BMI）和吸烟状况相匹配的对照者进行比较。使用多因素逻辑回归分析计算跨MPV四分位数的结肠癌比值比（OR）和95%置信区间（CI）。
与对照组相比，结肠癌患者的MPV更高。手术切除肿瘤导致MPV水平显著降低（11.4 fL对10.7 fL；p<0.001）。发现MPV与肿瘤-结节-转移（TNM）分期呈正相关。此外，在调整其他危险因素后，根据MPV四分位数的结肠癌OR（95%CI）分别为1.000、2.238（1.014 - 4.943）、3.410（1.528 - 7.613）和5.379（2.372 - 12.198）。
研究结果表明，与对照组相比，结肠癌患者的MPV水平更高，且手术后降低。此外，发现MPV与结肠癌的存在独立相关。有必要进一步研究评估MPV作为结肠癌新型诊断筛查工具的效用。
