Kanecki Krzysztof, Goryński Paweł, Tarka Patryk, Wierzba Waldemar, Tyszko Piotr
Department of Social Medicine and Public Health, Medical University of Warsaw, Poland.
National Institute of Public Health - National Institute of Hygiene, Poland.
Ann Agric Environ Med. 2017 May 11;24(2):240-244. doi: 10.5604/12321966.1233570.
[b] Abstract Introduction.[/b] Systemic sclerosis (SSc) is a rare and potentially severe connective tissue disease, characterized by skin fibrosis and involvement of internal organs. Because of its rarity and heterogeneous clinical presentation, reliable epidemiological studies on SSc have been particularly difficult to carry out. [b]Objectives[/b]. The purpose of this study was to present SSc epidemiology among hospitalized patients in Poland.
The analysis was based on population-based administrative data, taken from a Polish hospital morbidity study carried out by the National Institute of Public Health between January 2008 - December 2012. [b]Results[/b]. Analyzed data covered 9,049 hospitalization records. The final sample comprised 3,653 patients with first-time hospitalizations for SSc. The average age of the sample was 53 years (SD 16.2; range 0-91 years); 84% of patients were female and 16% male. Based on hospitalization registers, the average SSc incidence was estimated to be 1.9/100,000 per year and peak age of incidence was 55 years. The point prevalence was estimated to be 9.4/100,000 at the end of 2012. SSc was more common in females, with F:M ratio ranging from 6.2:1-4.6:1 depending on the year. Analysis of hospitalization trends revealed that overall numbers of SSc hospitalizations increased, while first-time hospitalizations decreased between 2008-2012. Clusters of higher incidence were observed in more rural regions vs. urban regions. [b]Conclusion[/b]. Estimated incidence of SSc in Poland was comparable to reported incidence in other European countries. Analysis of demographic factors and reports of clusters of higher incidence may suggest the existence of environmental risk factors for the development of SSc. These observations may require further research.
[b]摘要 引言[/b]。系统性硬化症（SSc）是一种罕见且可能严重的结缔组织病，其特征为皮肤纤维化和内脏受累。由于其罕见性和临床表现的异质性，关于SSc的可靠流行病学研究一直特别难以开展。[b]目的[/b]。本研究的目的是呈现波兰住院患者中的SSc流行病学情况。
分析基于以人群为基础的行政数据，取自2008年1月至2012年12月期间由国家公共卫生研究所开展的一项波兰医院发病率研究。[b]结果[/b]。分析的数据涵盖9049份住院记录。最终样本包括3653例首次因SSc住院的患者。样本的平均年龄为53岁（标准差16.2；范围0 - 91岁）；84%的患者为女性，16%为男性。根据住院登记册，SSc的平均发病率估计为每年1.9/10万，发病高峰年龄为55岁。2012年末的点患病率估计为9.4/10万。SSc在女性中更为常见，根据年份不同，女性与男性的比例在6.2:1至4.6:1之间。住院趋势分析显示，2008 - 2012年间，SSc住院的总体数量增加，而首次住院数量减少。在农村地区比城市地区观察到更高的发病率聚集区。[b]结论[/b]。波兰SSc的估计发病率与其他欧洲国家报告的发病率相当。对人口统计学因素和更高发病率聚集区报告的分析可能提示存在SSc发病的环境危险因素。这些观察结果可能需要进一步研究。
