Chhibber Sanjay, Gondil Vijay S, Sharma Samrita, Kumar Munish, Wangoo Nishima, Sharma Rohit K
Department of Microbiology, Basic Medical Sciences, Panjab UniversityChandigarh, India.
Department of Chemistry, Panjab UniversityChandigarh, India.
Front Microbiol. 2017 Jun 16;8:1104. doi: 10.3389/fmicb.2017.01104. eCollection 2017.
Treating pathogens is becoming challenging because of multidrug resistance and availability of limited alternative therapies which has further confounded this problem. The situation becomes more alarming when multidrug resistant pathogens form a 3D structure known as biofilm. Biofilms are formed in most of the infections especially in chronic infections where it is difficult to eradicate them by conventional antibiotic therapy. Chemically synthesized nanoparticles are known to have antibiofilm activity but in the present study, an attempt was made to use amino acid functionalized silver nanoparticles alone and in combination with gentamicin to eradicate biofilm. Amino acid functionalized silver nanoparticles were not only able to disrupt biofilm but also led to the lowering of gentamicin dose when used in combination. To the best of our knowledge, this is the first study demonstrating the application of amino acid functionalized silver nanoparticles in the eradication of young and old biofilm.
由于多重耐药性以及有限的替代疗法，治疗病原体正变得具有挑战性，这进一步加剧了该问题。当多重耐药病原体形成一种称为生物膜的三维结构时，情况变得更加令人担忧。生物膜在大多数感染中形成，尤其是在慢性感染中，传统抗生素疗法难以根除它们。已知化学合成的纳米颗粒具有抗生物膜活性，但在本研究中，尝试单独使用氨基酸功能化银纳米颗粒以及将其与庆大霉素联合使用来根除生物膜。氨基酸功能化银纳米颗粒不仅能够破坏生物膜，而且在联合使用时还能降低庆大霉素的剂量。据我们所知，这是第一项证明氨基酸功能化银纳米颗粒在根除新旧生物膜中的应用的研究。
