Hatakeyama Hiroto
Laboratory of Clinical Pharmacology and Pharmacometrics, Graduate School of Pharmaceutical Sciences, Chiba University.
Chem Pharm Bull (Tokyo). 2017;65(7):612-617. doi: 10.1248/cpb.c17-00068.
Significant progress has been achieved in the development of stimuli-responsive nanocarriers for drug delivery, diagnosis, and therapy. Various types of triggers are utilized in the development of nanocarrier delivery. Endogenous factors such as changes in pH, redox, gradient, and enzyme concentration which are linked to disease progression have been utilized for controlling biodistribution and releasing drugs from nanocarriers, as well as increasing subsequent pharmacological activity at the disease site. Nanocarriers which respond to artificially-induced exogenous factors (such as temperature, light, magnetic field, and ultrasound) have also been developed. This review aims to discuss recent advances in the design of stimuli-responsive nanocarriers which appear to have a promising future in medicine.
在用于药物递送、诊断和治疗的刺激响应性纳米载体的开发方面已经取得了重大进展。在纳米载体递送的开发中利用了各种类型的触发因素。与疾病进展相关的内源性因素，如pH值、氧化还原、梯度和酶浓度的变化，已被用于控制纳米载体的生物分布和药物释放，以及增强疾病部位的后续药理活性。还开发了对人工诱导的外源性因素（如温度、光、磁场和超声）作出响应的纳米载体。本综述旨在讨论刺激响应性纳米载体设计的最新进展，这些进展在医学领域似乎有着广阔的前景。
