Yamada Kazuo, Kamagata Eiichiro
Department of Psychiatry, Tohoku Medical and Pharmaceutical University Hospital, 1-12-1 Fukumuro, Miyagino-ku, Sendai, 983-8512, Japan.
Keio University Law School, 2-15-45 Mita, Minato-ku, Tokyo, 108-8343, Japan.
Qual Life Res. 2017 Nov;26(11):3069-3073. doi: 10.1007/s11136-017-1642-1. Epub 2017 Jul 3.
Premenstrual dysphoric disorder (PMDD) refers to the depression that occurs during the premenstrual phase and remits soon after the onset of menses. It affects the quality of life (QOL) of patients with PMDD. Therefore, this preliminary survey from chart recordings aimed to understand the symptom appearance and QOL reduction patterns in patients with PMDD, and to examine the extent of the loss of their quality-adjusted life years (QALYs).
Participants were 66 untreated female patients with PMDD. Data on symptom appearance and QOL reduction during the menstrual cycle, and the EuroQoL-5D (EQ-5D) scores during the premenstrual phase and immediately after the completion of a menstrual period were collected.
The mean EQ-5D score of the 66 patients with PMDD was 0.795 ± 0.120 (range 0.362-0.949), indicating that their expected mean loss of QALYs was about 0.14 years.
If untreated, PMDD is expected to cause a mean loss of QALYs of about 0.14 years. However, on accounting for the period from disease development to menopause, and subtracting the menstruation-free periods such as pregnancy and breastfeeding, patients with untreated PMDD are expected to experience a QALY loss of about 3 years during their lifetime.
经前烦躁障碍（PMDD）是指在经前期出现并在月经开始后不久缓解的抑郁症状。它会影响PMDD患者的生活质量（QOL）。因此，这项基于病历记录的初步调查旨在了解PMDD患者的症状表现和生活质量下降模式，并评估其质量调整生命年（QALY）的损失程度。
研究对象为66名未经治疗的PMDD女性患者。收集月经周期中症状出现和生活质量下降的数据，以及经前期和月经结束后即刻的欧洲五维健康量表（EQ-5D）评分。
66例PMDD患者的EQ-5D平均评分为0.795±0.120（范围0.362-0.949），表明其预期的QALY平均损失约为0.14年。
如果不进行治疗，PMDD预计会导致平均约0.14年的QALY损失。然而，考虑到从疾病发展到绝经的时间段，并减去妊娠和哺乳等无月经时期，未经治疗的PMDD患者一生中预计会经历约3年的QALY损失。
