Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
Department of Pathology and Cell Biology, Naomi Berrie Diabetes Center, College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
Protein Cell. 2018 Feb;9(2):152-163. doi: 10.1007/s13238-017-0434-2. Epub 2017 Jul 4.
The induction of brown-like adipocyte development in white adipose tissue (WAT) confers numerous metabolic benefits by decreasing adiposity and increasing energy expenditure. Therefore, WAT browning has gained considerable attention for its potential to reverse obesity and its associated co-morbidities. However, this perspective has been tainted by recent studies identifying the detrimental effects of inducing WAT browning. This review aims to highlight the adverse outcomes of both overactive and underactive browning activity, the harmful side effects of browning agents, as well as the molecular brake-switch system that has been proposed to regulate this process. Developing novel strategies that both sustain the metabolic improvements of WAT browning and attenuate the related adverse side effects is therefore essential for unlocking the therapeutic potential of browning agents in the treatment of metabolic diseases.
棕色样前体细胞在白色脂肪组织（WAT）中的诱导分化可以通过减少脂肪堆积和增加能量消耗来带来许多代谢益处。因此，WAT 的褐变因其逆转肥胖及其相关合并症的潜力而受到广泛关注。然而，最近的研究发现诱导 WAT 褐变会产生有害影响，这一观点受到了质疑。本综述旨在强调过度和不足的褐变活性的不良后果、褐变剂的有害副作用，以及提出的调节该过程的分子制动开关系统。因此，开发既能维持 WAT 褐变的代谢改善，又能减轻相关不良反应的新策略，对于挖掘褐变剂在代谢性疾病治疗中的治疗潜力至关重要。
