从阿根廷和加拿大的多克隆临床大肠杆菌中分离出的携带mcr-1质粒的分子特征及新型mcr-1变体

Molecular characteristics of mcr-1-carrying plasmids and new mcr-1 variant recovered from polyclonal clinical Escherichia coli from Argentina and Canada.

作者信息

Tijet Nathalie, Faccone Diego, Rapoport Melina, Seah Christine, Pasterán Fernando, Ceriana Paola, Albornoz Ezequiel, Corso Alejandra, Petroni Alejandro, Melano Roberto G

机构信息

Public Health Ontario Laboratory, Toronto, Ontario, Canada.

Servicio Antimicrobianos, National and Regional Reference Laboratory in Antimicrobial Resistance, Instituto Nacional de Enfermedades Infecciosas (INEI)-ANLIS "Dr. C. Malbran", Buenos Aires, Argentina.

出版信息

PLoS One. 2017 Jul 5;12(7):e0180347. doi: 10.1371/journal.pone.0180347. eCollection 2017.

We have characterized nine mcr-1-harboring plasmids from clinical Escherichia coli isolates previously described in Argentina and Canada. Three of these plasmids carried a mcr-1-variant called here mcr-1.5. All these E. coli isolates were not clonally related and were recovered in different years and locations. However, their mcr-1-harboring plasmids showed high identity among them and to others characterized in other countries, which strongly suggests that this plasmid-type is playing an important role in spreading this mechanism of resistance to polymyxins.