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致肾盂肾炎大肠杆菌中编码与球系列糖脂受体结合的黏附素的多种基因形式。

Multiple forms of genes in pyelonephritogenic Escherichia coli encoding adhesins binding globoseries glycolipid receptors.

作者信息

Hull S, Clegg S, Sanborg Eden C, Hull R

出版信息

Infect Immun. 1985 Jan;47(1):80-3. doi: 10.1128/iai.47.1.80-83.1985.

DOI:10.1128/iai.47.1.80-83.1985
PMID:2856916
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC261471/
Abstract

Earlier studies have shown that the majority of Escherichia coli isolates from urinary tract infections which possess a D-mannose-resistant adhesin contain gene sequences homologous to the pap pilus gene sequences encoded on the recombinant plasmid pRHU845. In this report, several E. coli isolates from urinary tract infections were examined to determined the arrangement of pap-related sequences. Copies of gene sequences homologous to the entire pap operon were found to exist at multiple sites in the chromosomes of some strains. The position of the pap operon(s) with respect to adjacent sequences was also found to be variable.

摘要

早期研究表明，从尿路感染中分离出的大多数具有D-甘露糖抗性粘附素的大肠杆菌菌株含有与重组质粒pRHU845上编码的pap菌毛基因序列同源的基因序列。在本报告中，检测了几株从尿路感染中分离出的大肠杆菌菌株，以确定pap相关序列的排列情况。发现与整个pap操纵子同源的基因序列拷贝存在于一些菌株染色体的多个位点。还发现pap操纵子相对于相邻序列的位置是可变的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5496/261471/b3779ed06013/iai00118-0098-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5496/261471/2cfe56ab5ff6/iai00118-0097-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5496/261471/b3779ed06013/iai00118-0098-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5496/261471/2cfe56ab5ff6/iai00118-0097-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5496/261471/b3779ed06013/iai00118-0098-a.jpg

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Infect Immun. 1985 Jan;47(1):80-3. doi: 10.1128/iai.47.1.80-83.1985.
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本文引用的文献

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Inhibition of experimental ascending urinary tract infection by an epithelial cell-surface receptor analogue.上皮细胞表面受体类似物对实验性上行性尿路感染的抑制作用
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Genetics of hemolysin of Escherichia coli.大肠杆菌溶血素的遗传学
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Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface.细菌黏附：介导细菌附着于黏膜表面的黏附素-受体相互作用。
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Functional and structural homology among regulatory cistrons of pili-adhesin determinants in Escherichia coli.大肠杆菌菌毛粘附素决定簇调控顺反子间的功能和结构同源性
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Characterization of P fimbriae on O1, O7, O75, rough, and nontypable strains of Escherichia coli.大肠杆菌O1、O7、O75、粗糙型和不可分型菌株上P菌毛的特性分析
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Molecular cloning of the Escherichia coli O75X adhesin.大肠杆菌O75X黏附素的分子克隆
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Analysis of the genetic determinants coding for the S-fimbrial adhesin (sfa) in different Escherichia coli strains causing meningitis or urinary tract infections.对不同引起脑膜炎或尿路感染的大肠杆菌菌株中编码S-菌毛黏附素（sfa）的遗传决定因素的分析。
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Genetic relationships and clonal structure of strains of Escherichia coli causing neonatal septicemia and meningitis.引起新生儿败血症和脑膜炎的大肠杆菌菌株的遗传关系和克隆结构。
Infect Immun. 1986 Apr;52(1):213-22. doi: 10.1128/iai.52.1.213-222.1986.
10
Chromosomal map position of genes encoding P adhesins in uropathogenic Escherichia coli.编码尿路致病性大肠杆菌中P菌毛黏附素的基因的染色体图谱位置。
Infect Immun. 1986 Feb;51(2):693-5. doi: 10.1128/iai.51.2.693-695.1986.
J Infect Dis. 1981 Mar;143(3):325-45. doi: 10.1093/infdis/143.3.325.
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Bacterial adherence.细菌黏附
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Bacterial adherence--a pathogenetic mechanism in urinary tract infections caused by Escherichia coli.细菌黏附——大肠杆菌引起尿路感染的一种致病机制。
Prog Allergy. 1983;33:175-88.
6
Gene clusters governing the production of hemolysin and mannose-resistant hemagglutination are closely linked in Escherichia coli serotype O4 and O6 isolates from urinary tract infections.在从尿路感染患者分离出的大肠杆菌O4和O6血清型菌株中，控制溶血素产生和甘露糖抗性血凝反应的基因簇紧密相连。
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Mannose-resistant haemagglutination and P antigen recognition are characteristic of Escherichia coli causing primary pyelonephritis.甘露糖抗性血凝和P抗原识别是引起原发性肾盂肾炎的大肠杆菌的特征。
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Frequency of gene sequences necessary for pyelonephritis-associated pili expression among isolates of Enterobacteriaceae from human extraintestinal infections.人类肠外感染的肠杆菌科分离株中与肾盂肾炎相关菌毛表达所需基因序列的频率。
Infect Immun. 1984 Mar;43(3):1064-7. doi: 10.1128/iai.43.3.1064-1067.1984.
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Target cell specificity of wild-type E. coli and mutants and clones with genetically defined adhesins.野生型大肠杆菌以及具有基因定义黏附素的突变体和克隆体的靶细胞特异性。
Prog Food Nutr Sci. 1983;7(3-4):75-89.
10
Nucleotide sequence of the papA gene encoding the Pap pilus subunit of human uropathogenic Escherichia coli.编码人源致病性大肠杆菌菌毛亚基PapA的papA基因的核苷酸序列。
J Bacteriol. 1984 Jan;157(1):330-3. doi: 10.1128/jb.157.1.330-333.1984.