Baillie A J, Florence A T, Hume L R, Muirhead G T, Rogerson A
J Pharm Pharmacol. 1985 Dec;37(12):863-8. doi: 10.1111/j.2042-7158.1985.tb04990.x.
Vesicles were prepared on hydration of a mixture of a single or double alkyl-chain, non-ionic surfactant with cholesterol. These vesicles, or 'niosomes', are capable of entrapping and retaining water soluble solutes such as carboxyfluorescein, are osmotically active and can be formulated to release entrapped solute slowly. The physical characteristics of the vesicles were found to be dependent on the method of production and three such methods, based on liposome technology, are described. The vesicles have been characterized by photon correlation spectroscopy, freeze fracture electron micrography, measurement of solute entrapment efficiency, and solute release rates. Vesicular forms of the single chain surfactant which could be formed under certain conditions in the absence of cholesterol are also described.
通过使单链或双链烷基链非离子表面活性剂与胆固醇的混合物水合来制备囊泡。这些囊泡，即“非离子型脂质体”，能够包封并保留水溶性溶质，如羧基荧光素，具有渗透活性，并且可以被制备成缓慢释放包封溶质的形式。发现囊泡的物理特性取决于生产方法，并描述了基于脂质体技术的三种此类方法。通过光子相关光谱法、冷冻断裂电子显微镜、溶质包封效率的测量和溶质释放速率对囊泡进行了表征。还描述了在某些条件下在无胆固醇的情况下可形成的单链表面活性剂的囊泡形式。
