Mahmoudi S, Roustaei M, Zaini F, Kordbacheh P, Safara M
Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Curr Med Mycol. 2015 Jun;1(2):7-12. doi: 10.18869/acadpub.cmm.1.2.7.
species constitute an important group of opportunistic fungi, which cause various clinical diseases. Considering the resistance of some species to conventional antifungal agents, treatment of such cases may be challenging and complicated. The purpose of this study was to evaluate and compare the antifungal activities of latex and fluconazole against different species.
A total of 150 isolates including (n=77), 28), (n=23), (n=15), (n=4), (n=1), (n=1) and (n=1) were included in this study. In vitro antifungal activities of latex and fluconazole against these species were evaluated, according to M27-A2 protocol on broth macrodilution method by the Clinical and Laboratory Standards Institute (CLSI).
Among 150 isolates, 98 isolates (65.33%), i.e., . (n=41), (n=23), (n=12) and (n=22) with minimal inhibitory concentration (MIC) ≤ 8 μg/ml were susceptible to fluconazole. Resistance to fluconazole was noted in 15 isolates, i.e., (n=10), (n=2), (n=1), (n=1), and (n=1), with MICs of 64 µg/ml. The remaining isolates (n=37) including (n=26), (n=3), (n=3), (n=1), (n=3) and (n=1) with MIC= 16-32 µg/ml showed dose-dependent susceptibility. The latex of was able to inhibit the growth of 30 out of 150 tested isolates with MIC range of 128-512 µg/ml. These isolates were as follows: (n=2), (n=4), (n=19), (n=2) and (n=3). Compared to other isolates, higher MIC values were noted for and (512 µg/ml), respectively.
The latex of showed notable antifungal activities against some pathogenic species. Therefore, it can be potentially used as an alternative antifungal agent in future. However, further research is required to identify its active components.
[物种名称]是一类重要的机会性真菌，可引发多种临床疾病。鉴于某些[物种名称]对传统抗真菌药物具有耐药性，此类病例的治疗可能具有挑战性且较为复杂。本研究旨在评估并比较[物种名称]乳胶和氟康唑对不同[物种名称]的抗真菌活性。
本研究共纳入150株[物种名称]分离株，其中包括[具体物种1]（n = 77）、[具体物种2]（n = 28）、[具体物种3]（n = 23）、[具体物种4]（n = 15）、[具体物种5]（n = 4）、[具体物种6]（n = 1）、[具体物种7]（n = 1）和[具体物种8]（n = 1）。根据美国临床和实验室标准协会（CLSI）的M27 - A2肉汤稀释法方案，评估了[物种名称]乳胶和氟康唑对这些[物种名称]的体外抗真菌活性。
在150株[物种名称]分离株中，98株（65.33%），即[具体物种1]（n = 41）、[具体物种2]（n = 23）、[具体物种3]（n = 12）和[具体物种4]（n = 22），最小抑菌浓度（MIC）≤8μg/ml，对氟康唑敏感。15株分离株对氟康唑耐药，即[具体物种5]（n = 10）、[具体物种6]（n = 2）、[具体物种7]（n = 1）、[具体物种8]（n = 1），MIC为64μg/ml。其余37株分离株，包括[具体物种9]（n = 26）、[具体物种10]（n = 3）、[具体物种11]（n = 3）、[具体物种12]（n = 1）、[具体物种13]（n = 3）和[具体物种14]（n = 1），MIC为16 - 32μg/ml，表现出剂量依赖性敏感性。[物种名称]乳胶能够抑制150株受试[物种名称]分离株中的30株生长，MIC范围为128 - 512μg/ml。这些分离株如下：[具体物种15]（n = 2）、[具体物种16]（n = 4）、[具体物种17]（n = 19）、[具体物种18]（n = 2）和[具体物种19]（n = 3）。与其他分离株相比，[具体物种20]和[具体物种21]的MIC值分别更高（512μg/ml）。
[物种名称]乳胶对某些致病性[物种名称]表现出显著的抗真菌活性。因此，它未来有可能用作替代抗真菌药物。然而，需要进一步研究以确定其活性成分。
