Runyoro D K B, Ngassapa O D, Matee M I N, Joseph C C, Moshi M J
Department of Pharmacognosy, School of Pharmacy, Muhimbili University College of Health Sciences, P.O. Box 65013, Dar es Salaam, Tanzania.
J Ethnopharmacol. 2006 Jun 30;106(2):158-65. doi: 10.1016/j.jep.2005.12.010. Epub 2006 Feb 3.
An ethnomedical survey in Coast, Dar es Salaam, Morogoro and Tanga regions of Tanzania has resulted in the identification of 36 plant species belonging to 21 plant families that are used traditionally for the treatment of Candida infections. Twenty-one plants constituting 58.3% of all collected plants are used to treat of oral candidiasis (Utando) one of the important signs of HIV/AIDS. The knowledge of traditional healers for the treatment of Candida infections has been highly supported by the literature in that 13 (36.1%) out of the 36 plants identified have been proven to be active against Candida albicans and/or other species of Candida. Also, some of the plants were reported to be active against other species of fungi including Cryptococcus neoformans, one of the important pathogenic fungi in HIV/AIDS. It can be seen that ethnomedical information from traditional healers provides a solid lead towards development of new drugs than random screening. The task that remains is to screen extracts prepared from these plants and perform a bioassay-guided fractionation of the active extracts so as to isolate the active compounds from these plants.
在坦桑尼亚的滨海、达累斯萨拉姆、莫罗戈罗和坦噶地区开展的一项民族医学调查，已鉴定出21个植物科的36种植物，这些植物在传统上用于治疗念珠菌感染。占所有采集植物58.3%的21种植物用于治疗口腔念珠菌病（乌坦多），这是艾滋病毒/艾滋病的重要体征之一。传统治疗师治疗念珠菌感染的知识得到了文献的高度支持，因为在鉴定出的36种植物中，有13种（36.1%）已被证明对白色念珠菌和/或其他念珠菌物种具有活性。此外，据报道，其中一些植物对包括新型隐球菌在内的其他真菌物种也有活性，新型隐球菌是艾滋病毒/艾滋病中的一种重要致病真菌。可以看出，传统治疗师的民族医学信息比随机筛选更能为新药开发提供可靠线索。剩下的任务是筛选从这些植物中制备的提取物，并对活性提取物进行生物测定导向的分级分离，以便从这些植物中分离出活性化合物。
